B1ZR70 (B1ZR70_OPITP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Oter_1275

Organism

Opitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP]

Taxonomic identifier

452637 [NCBI]

Taxonomic lineage

Bacteria › Verrucomicrobia › Opitutae › Opitutales › Opitutaceae › Opitutus

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACB74560.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	69 – 76	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B1ZR70 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: E0F89E8F22F5A2C8	FASTA	560	59,261
	10 20 30 40 50 60 MNPAGLTALE ISRRAQLRPI AEVAAQLGIA ADDLDLYGRY RAKLSLGLTR RLQDAPPGKL 70 80 90 100 110 120 VLMTAITPTP AGEGKTTTSI GLVDALNRIG RKAVVCLREP AIGPCFGMKG GGAGGGRAQV 130 140 150 160 170 180 VPMEDINLHF NGDFHAVTSA HNLLAAMLDS HLHFGNALGI DVRRVLWRRV MDMNDRALRE 190 200 210 220 230 240 LVIGLGGAGN SMPRESGFDI TAASEVMATL CFAESLPDLK ERFGRIAVAW NAARRLVTAN 250 260 270 280 290 300 DLKAAGAMTV LMRYAIQPNL VQTLEGSPAL IHGGPFGNIA HGCNSVTATK LGLRLAEFAV 310 320 330 340 350 360 TEAGFGADLG AEKFLNIKCR KTGLRPDVAV LVATIRALKY HGGVKVADLG RPDVAALTAG 370 380 390 400 410 420 LDNLRKHLEN LRAFGLPVVV AVNTFPSDTL EEWQVVAAAC AELGAPVARC EHFTRGGEGA 430 440 450 460 470 480 EDLARLVAQT AATPSRPIAF TYADDLPLLE KVRSVARAIY GADDVVPEGA TAEKLRGFEA 490 500 510 520 530 540 AGFGALPVCM AKTQYSFSAN PQLRNRPRGF KVPLRDARLN AGPGFVVIYT GEIMTMPGLP 550 560 KVPAAEAMDI DADGNTVGLF

References

[1]

"Complete sequence of Opitutus terrae PB90-1." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Smidt H., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001032 Genomic DNA. Translation: ACB74560.1.
RefSeq	YP_001818160.1. NC_010571.1.
3D structure databases
ProteinModelPortal	B1ZR70.
SMR	B1ZR70. Positions 9-558.
ModBase	Search...
Protein-protein interaction databases
STRING	B1ZR70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6206184.
GenomeReviews	Gene locus Oter_1275 in contig CP001032_GR.
KEGG	ote:Oter_1275.
PATRIC	22814057. VBIOpiTer17422_1324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1ZR70_OPITP

Accession

Primary (citable) accession number: B1ZR70

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)