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B1ZQS6 (AROB_OPITP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Oter_4556
OrganismOpitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP]
Taxonomic identifier452637 [NCBI]
Taxonomic lineageBacteria › Verrucomicrobia › Opitutae › Opitutales › Opitutaceae › Opitutus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_1000094558

Sequences

Sequence LengthMass (Da)Tools
B1ZQS6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 32C5AF7C0BC7AA11

FASTA36137,995
        10         20         30         40         50         60 
MPNTLTVDLG HRSYPIVFAA DVRNNVRDQV AELTTAGRKV AVFTDEQVAS AQVGALEAMF 

        70         80         90        100        110        120 
GSSPRLAFAP GESAKSLASF GRAMDFLAAQ KVDRRGVVFA FGGGVIGDLA GFIAASWLRG 

       130        140        150        160        170        180 
IDFYQVPTTL LAMVDSSVGG KTGINIPAGK NLVGAFHQPR GVFIGTDFLR TLPAREFAAG 

       190        200        210        220        230        240 
MAEVIKYGLL GDAALLELLE RAPLSFVSPE LAGVIRQCCA LKAAFVQADE RELAPEGGRA 

       250        260        270        280        290        300 
LLNLGHTFGH AIEQVTGYGV YLHGEAVAIG MCAAARLSAK LGHLGGADVA RVDAVVAAHR 

       310        320        330        340        350        360 
LPVKLRTPLV LMDLLAAMAR DKKVRAGMPR FVVLRKLGEA VTQDDVPAEL AAECFREVGA 


S

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References

[1]"Complete sequence of Opitutus terrae PB90-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Smidt H., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001032 Genomic DNA. Translation: ACB77827.1.
RefSeqYP_001821427.1. NC_010571.1.

3D structure databases

ProteinModelPortalB1ZQS6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1ZQS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6207474.
GenomeReviewsGene locus Oter_4556 in contig CP001032_GR.
KEGGote:Oter_4556.
PATRIC22820949. VBIOpiTer17422_4730.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMALGQSDFT.
ProtClustDBCLSK2800867.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_OPITP
AccessionPrimary (citable) accession number: B1ZQS6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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