B1ZQR5 (B1ZQR5_OPITP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 2 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 2 HAMAP MF_00444

Gene names

Name:	clpP2 HAMAP MF_00444
Ordered Locus Names:	Oter_4545

Organism

Opitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP]

Taxonomic identifier

452637 [NCBI]

Taxonomic lineage

Bacteria › Verrucomicrobia › Opitutae › Opitutales › Opitutaceae › Opitutus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. RuleBase RU003567 HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	119	1	By similarity HAMAP MF_00444
	Active site	144	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	B1ZQR5 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 9D61C6D6D405DEAA	FASTA	216	23,819
	10 20 30 40 50 60 MHFDNLQPGL SAPVPRLDDD DDDDEHEEAA PKARALVGAM IQKKFLRQRK IFLWGAVTDE 70 80 90 100 110 120 TAKDMTEKLL YLEAVDPGKE ITFYINSPGG SITAGMAVFD TMRLITSPIT VIVTGMAASM 130 140 150 160 170 180 GSILLCGAPK GRRLLYPHAR VLIHQPLISG RMVGPATDIN IQAKEMEKIR AELNQILADS 190 200 210 SGQPIERINQ DTDRDFYLNA KEAIAYGLAD RIVDKI

References

[1]

"Complete sequence of Opitutus terrae PB90-1." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Smidt H., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001032 Genomic DNA. Translation: ACB77816.1.
RefSeq	YP_001821416.1. NC_010571.1.
3D structure databases
ProteinModelPortal	B1ZQR5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1ZQR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6208098.
GenomeReviews	Gene locus Oter_4545 in contig CP001032_GR.
KEGG	ote:Oter_4545.
PATRIC	22820927. VBIOpiTer17422_4719.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG558421.
OMA	FSEPVTD.
ProtClustDB	CLSK574113.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1ZQR5_OPITP

Accession

Primary (citable) accession number: B1ZQR5

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)