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B1ZJK3

- B1ZJK3_METPB

UniProt

B1ZJK3 - B1ZJK3_METPB

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Mpop_3338

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysis
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMPOP441620:GHMI-3394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Mpop_3338Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000007136: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_3338.

Structurei

3D structure databases

ProteinModelPortaliB1ZJK3.
SMRiB1ZJK3. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZJK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVANPV VELDGDEMTR IIWAEIKNKL IHPYLDLDLD YYDLGVEHRD
60 70 80 90 100
ATNDQVTIDA AEAIKRHGVG VKCATITPDE ARVEEFKLKE MWRSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICSNVPRL VPGWTQPFVI GRHAYGDQYR ATDFKVPGKG
160 170 180 190 200
RLTIKFEGDD GTVIEKEVFK FPDAGVAMSM YNLDQSIIDF ARASFNYGLA
210 220 230 240 250
RKYPVYLSTK NTILKTYDGR FKDLFQKVFD EEFKSKFQSL GLTYEHRLID
260 270 280 290 300
DMVASCLKWS GGYVWACKNY DGDVQSDTAA QGFGSLGLMT SVLMTPDGQT
310 320 330 340 350
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTRGLAH RAKLDGNADL
360 370 380 390 400
AKFASTLEKV CVDTVEAGHM TKDLALLVGP DQKWLTTNGF LDKVDENLKA

AMAV
Length:404
Mass (Da):45,083
Last modified:May 20, 2008 - v1
Checksum:i3B8BE18B0B4817E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB81489.1.
RefSeqiYP_001926024.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaiACB81489; ACB81489; Mpop_3338.
GeneIDi6311289.
KEGGimpo:Mpop_3338.
PATRICi22563978. VBIMetPop124700_3394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB81489.1 .
RefSeqi YP_001926024.1. NC_010725.1.

3D structure databases

ProteinModelPortali B1ZJK3.
SMRi B1ZJK3. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441620.Mpop_3338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB81489 ; ACB81489 ; Mpop_3338 .
GeneIDi 6311289.
KEGGi mpo:Mpop_3338.
PATRICi 22563978. VBIMetPop124700_3394.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci MPOP441620:GHMI-3394-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-705 / NCIMB 13946 / BJ001Imported.

Entry informationi

Entry nameiB1ZJK3_METPB
AccessioniPrimary (citable) accession number: B1ZJK3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3