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B1ZJK3 (B1ZJK3_METPB) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B1ZJK3 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 3B8BE18B0B4817E9

FASTA40445,083
        10         20         30         40         50         60 
MAKIKVANPV VELDGDEMTR IIWAEIKNKL IHPYLDLDLD YYDLGVEHRD ATNDQVTIDA 

        70         80         90        100        110        120 
AEAIKRHGVG VKCATITPDE ARVEEFKLKE MWRSPNGTIR NILGGVIFRE PIICSNVPRL 

       130        140        150        160        170        180 
VPGWTQPFVI GRHAYGDQYR ATDFKVPGKG RLTIKFEGDD GTVIEKEVFK FPDAGVAMSM 

       190        200        210        220        230        240 
YNLDQSIIDF ARASFNYGLA RKYPVYLSTK NTILKTYDGR FKDLFQKVFD EEFKSKFQSL 

       250        260        270        280        290        300 
GLTYEHRLID DMVASCLKWS GGYVWACKNY DGDVQSDTAA QGFGSLGLMT SVLMTPDGQT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTRGLAH RAKLDGNADL AKFASTLEKV 

       370        380        390        400 
CVDTVEAGHM TKDLALLVGP DQKWLTTNGF LDKVDENLKA AMAV 

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium populi BJ001."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marx C., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-705 / NCIMB 13946 / BJ001.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001029 Genomic DNA. Translation: ACB81489.1.
RefSeqYP_001926024.1. NC_010725.1.

3D structure databases

ProteinModelPortalB1ZJK3.
SMRB1ZJK3. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING441620.Mpop_3338.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB81489; ACB81489; Mpop_3338.
GeneID6311289.
KEGGmpo:Mpop_3338.
PATRIC22563978. VBIMetPop124700_3394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycMPOP441620:GHMI-3394-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1ZJK3_METPB
AccessionPrimary (citable) accession number: B1ZJK3
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 13, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)