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Protein

Isocitrate dehydrogenase [NADP]

Gene

Mpop_3338

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei210Critical for catalysisUniRule annotation1
Metal bindingi250Magnesium or manganeseUniRule annotation1
Binding sitei258NADPUniRule annotation1
Metal bindingi273Magnesium or manganeseUniRule annotation1
Binding sitei326NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi308 – 313NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMPOP441620:GHMI-3351-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Mpop_3338Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000007136 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_3338

Structurei

3D structure databases

ProteinModelPortaliB1ZJK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 394Iso_dhInterPro annotationAdd BLAST386

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N Bacteria
COG0538 LUCA
HOGENOMiHOG000019858
KOiK00031
OMAiAMGMYNQ
OrthoDBiPOG091H0JP0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZJK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKVANPV VELDGDEMTR IIWAEIKNKL IHPYLDLDLD YYDLGVEHRD
60 70 80 90 100
ATNDQVTIDA AEAIKRHGVG VKCATITPDE ARVEEFKLKE MWRSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICSNVPRL VPGWTQPFVI GRHAYGDQYR ATDFKVPGKG
160 170 180 190 200
RLTIKFEGDD GTVIEKEVFK FPDAGVAMSM YNLDQSIIDF ARASFNYGLA
210 220 230 240 250
RKYPVYLSTK NTILKTYDGR FKDLFQKVFD EEFKSKFQSL GLTYEHRLID
260 270 280 290 300
DMVASCLKWS GGYVWACKNY DGDVQSDTAA QGFGSLGLMT SVLMTPDGQT
310 320 330 340 350
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTRGLAH RAKLDGNADL
360 370 380 390 400
AKFASTLEKV CVDTVEAGHM TKDLALLVGP DQKWLTTNGF LDKVDENLKA

AMAV
Length:404
Mass (Da):45,083
Last modified:May 20, 2008 - v1
Checksum:i3B8BE18B0B4817E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA Translation: ACB81489.1
RefSeqiWP_012455206.1, NC_010725.1

Genome annotation databases

EnsemblBacteriaiACB81489; ACB81489; Mpop_3338
GeneIDi32086844
KEGGimpo:Mpop_3338

Similar proteinsi

Entry informationi

Entry nameiB1ZJK3_METPB
AccessioniPrimary (citable) accession number: B1ZJK3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health