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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Mpop_0484
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000007136 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001968151 – 557Formate--tetrahydrofolate ligaseAdd BLAST557

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_0484.

Structurei

3D structure databases

ProteinModelPortaliB1ZJ88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZJ88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDIEIARA ATLKPIAQVA ERIGIPDEAL HNYGKHIAKI DHGFIKSLEG
60 70 80 90 100
KPEGKLVLVT AISPTPAGEG KTTTTVGLGD ALNRIGQRAV MCLREPSLGP
110 120 130 140 150
CFGMKGGAAG GGKAQVVPME QINLHFTGDF HAITSAHSLA AALIDNHVYW
160 170 180 190 200
ANELNIDVRR IHWRRVVDMN DRALRAINQS LGGVANGFPR EDGFDITVAS
210 220 230 240 250
EVMAVFCLAR DLADLEERLG RIVIAETRDR KPVTLADVKA TGAMTVLLKD
260 270 280 290 300
ALQPNLVQTL EGNPALIHGG PFANIAHGCN SVIATQTGLR LADYVVTEAG
310 320 330 340 350
FGADLGAEKF IDIKCRQTGL KPSAVVIVAT VRALKMHGGV NKKDLQGENL
360 370 380 390 400
DALEKGFANL ERHVKNVRGF GLPVVVGVNH FFQDTDAEHA KLKELCRDRL
410 420 430 440 450
QVEAITCKHW AEGGAGAEEL AQAVVKLAEG EQKPLTFAYD TETKLTDKIK
460 470 480 490 500
AIATKLYGAA DIQIESKAAT KLAGFEKDGY GHLPICMAKT QYSFSTDPTL
510 520 530 540 550
MGAPSGHLVS VRDVRLSAGA GFVVAICGEI MTMPGLPKVP AADTIRLDAN

GQIDGLF
Length:557
Mass (Da):59,441
Last modified:May 20, 2008 - v1
Checksum:i0C09871320DD2382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA. Translation: ACB78662.1.
RefSeqiWP_012452420.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaiACB78662; ACB78662; Mpop_0484.
KEGGimpo:Mpop_0484.
PATRICi22558100. VBIMetPop124700_0506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA. Translation: ACB78662.1.
RefSeqiWP_012452420.1. NC_010725.1.

3D structure databases

ProteinModelPortaliB1ZJ88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441620.Mpop_0484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB78662; ACB78662; Mpop_0484.
KEGGimpo:Mpop_0484.
PATRICi22558100. VBIMetPop124700_0506.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS_METPB
AccessioniPrimary (citable) accession number: B1ZJ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.