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B1ZEK3

- B1ZEK3_METPB

UniProt

B1ZEK3 - B1ZEK3_METPB

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Mpop_2912

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently.
Binds 2 lipoyl cofactors covalently.
Binds 3 lipoyl cofactors covalently.

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciMPOP441620:GHMI-2966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:Mpop_2912Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000007136: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_2912.

Structurei

3D structure databases

ProteinModelPortaliB1ZEK3.
SMRiB1ZEK3. Positions 3-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPISNIRK.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZEK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPINVLMPAL SPTMEKGNLA KWLKKEGDAI KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDEGVLAKIL VAEGTADVPV NELIALIAEE GEDPGSVEAP KGGEAKGEAK
110 120 130 140 150
TAPVEPKGTP DQNAAPDGAH ASYARVDQAP EGAKPNGAAQ PGASGGRVFA
160 170 180 190 200
SPLARRIAKQ EGIDLSAVKG SGPHGRVIQR DVQAAIEGGT AKAGAAAKPE
210 220 230 240 250
TKAPTPAADK PAPKAAPTGG APAGLSLDQV KGFYEKGSFE EVPLDGMRKT
260 270 280 290 300
IAKRLTEAMQ VAPHFYLTVD CELDALMKLR ETLNGSAGKD KDGKPLFKLS
310 320 330 340 350
VNDFVIKAMG LALTRVPAAN AVWAEDRILR FKHAEVGVAV AIDGGLFTPV
360 370 380 390 400
IRKADQKTLS TISNEMKDFA GRARAKKLKP EEYQGGVTSV SNLGMFGIKH
410 420 430 440 450
FTAVINPPQS TILAVGAGEK RVVVKDGAPA VVQAMTATLS CDHRVLDGAL
460 470
GAELIAAFKG LIENPMGMLV
Length:470
Mass (Da):48,817
Last modified:May 20, 2008 - v1
Checksum:i1623449D02EAE6EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB81067.1.
RefSeqiYP_001925602.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaiACB81067; ACB81067; Mpop_2912.
GeneIDi6310324.
KEGGimpo:Mpop_2912.
PATRICi22563114. VBIMetPop124700_2964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB81067.1 .
RefSeqi YP_001925602.1. NC_010725.1.

3D structure databases

ProteinModelPortali B1ZEK3.
SMRi B1ZEK3. Positions 3-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441620.Mpop_2912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB81067 ; ACB81067 ; Mpop_2912 .
GeneIDi 6310324.
KEGGi mpo:Mpop_2912.
PATRICi 22563114. VBIMetPop124700_2964.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281566.
KOi K00627.
OMAi PISNIRK.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci MPOP441620:GHMI-2966-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-705 / NCIMB 13946 / BJ001Imported.

Entry informationi

Entry nameiB1ZEK3_METPB
AccessioniPrimary (citable) accession number: B1ZEK3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3