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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Mpop_2912

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
LigandPyruvateImported

Enzyme and pathway databases

BioCyciMPOP441620:GHMI-2927-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:Mpop_2912Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000007136 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_2912

Structurei

3D structure databases

ProteinModelPortaliB1ZEK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini149 – 186Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
KOiK00627
OMAiSWRLGCD
OrthoDBiPOG091H0NG1

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZEK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINVLMPAL SPTMEKGNLA KWLKKEGDAI KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDEGVLAKIL VAEGTADVPV NELIALIAEE GEDPGSVEAP KGGEAKGEAK
110 120 130 140 150
TAPVEPKGTP DQNAAPDGAH ASYARVDQAP EGAKPNGAAQ PGASGGRVFA
160 170 180 190 200
SPLARRIAKQ EGIDLSAVKG SGPHGRVIQR DVQAAIEGGT AKAGAAAKPE
210 220 230 240 250
TKAPTPAADK PAPKAAPTGG APAGLSLDQV KGFYEKGSFE EVPLDGMRKT
260 270 280 290 300
IAKRLTEAMQ VAPHFYLTVD CELDALMKLR ETLNGSAGKD KDGKPLFKLS
310 320 330 340 350
VNDFVIKAMG LALTRVPAAN AVWAEDRILR FKHAEVGVAV AIDGGLFTPV
360 370 380 390 400
IRKADQKTLS TISNEMKDFA GRARAKKLKP EEYQGGVTSV SNLGMFGIKH
410 420 430 440 450
FTAVINPPQS TILAVGAGEK RVVVKDGAPA VVQAMTATLS CDHRVLDGAL
460 470
GAELIAAFKG LIENPMGMLV
Length:470
Mass (Da):48,817
Last modified:May 20, 2008 - v1
Checksum:i1623449D02EAE6EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA Translation: ACB81067.1
RefSeqiWP_012454787.1, NC_010725.1

Genome annotation databases

EnsemblBacteriaiACB81067; ACB81067; Mpop_2912
GeneIDi32087583
KEGGimpo:Mpop_2912

Similar proteinsi

Entry informationi

Entry nameiB1ZEK3_METPB
AccessioniPrimary (citable) accession number: B1ZEK3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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