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B1ZEK3

- B1ZEK3_METPB

UniProt

B1ZEK3 - B1ZEK3_METPB

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Mpop_2912

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciMPOP441620:GHMI-2966-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:Mpop_2912Imported
    OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
    Taxonomic identifieri441620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000007136: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi441620.Mpop_2912.

    Structurei

    3D structure databases

    ProteinModelPortaliB1ZEK3.
    SMRiB1ZEK3. Positions 3-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281566.
    KOiK00627.
    OMAiPISNIRK.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1ZEK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPINVLMPAL SPTMEKGNLA KWLKKEGDAI KSGDVIAEIE TDKATMEVEA    50
    VDEGVLAKIL VAEGTADVPV NELIALIAEE GEDPGSVEAP KGGEAKGEAK 100
    TAPVEPKGTP DQNAAPDGAH ASYARVDQAP EGAKPNGAAQ PGASGGRVFA 150
    SPLARRIAKQ EGIDLSAVKG SGPHGRVIQR DVQAAIEGGT AKAGAAAKPE 200
    TKAPTPAADK PAPKAAPTGG APAGLSLDQV KGFYEKGSFE EVPLDGMRKT 250
    IAKRLTEAMQ VAPHFYLTVD CELDALMKLR ETLNGSAGKD KDGKPLFKLS 300
    VNDFVIKAMG LALTRVPAAN AVWAEDRILR FKHAEVGVAV AIDGGLFTPV 350
    IRKADQKTLS TISNEMKDFA GRARAKKLKP EEYQGGVTSV SNLGMFGIKH 400
    FTAVINPPQS TILAVGAGEK RVVVKDGAPA VVQAMTATLS CDHRVLDGAL 450
    GAELIAAFKG LIENPMGMLV 470
    Length:470
    Mass (Da):48,817
    Last modified:May 20, 2008 - v1
    Checksum:i1623449D02EAE6EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB81067.1.
    RefSeqiYP_001925602.1. NC_010725.1.

    Genome annotation databases

    EnsemblBacteriaiACB81067; ACB81067; Mpop_2912.
    GeneIDi6310324.
    KEGGimpo:Mpop_2912.
    PATRICi22563114. VBIMetPop124700_2964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB81067.1 .
    RefSeqi YP_001925602.1. NC_010725.1.

    3D structure databases

    ProteinModelPortali B1ZEK3.
    SMRi B1ZEK3. Positions 3-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441620.Mpop_2912.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB81067 ; ACB81067 ; Mpop_2912 .
    GeneIDi 6310324.
    KEGGi mpo:Mpop_2912.
    PATRICi 22563114. VBIMetPop124700_2964.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281566.
    KOi K00627.
    OMAi PISNIRK.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci MPOP441620:GHMI-2966-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marx C., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-705 / NCIMB 13946 / BJ001Imported.

    Entry informationi

    Entry nameiB1ZEK3_METPB
    AccessioniPrimary (citable) accession number: B1ZEK3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3