Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Mpop_2912

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:Mpop_2912Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000007136 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_2912.

Structurei

3D structure databases

ProteinModelPortaliB1ZEK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPHGRIQA.
OrthoDBiPOG091H0NG1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZEK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINVLMPAL SPTMEKGNLA KWLKKEGDAI KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDEGVLAKIL VAEGTADVPV NELIALIAEE GEDPGSVEAP KGGEAKGEAK
110 120 130 140 150
TAPVEPKGTP DQNAAPDGAH ASYARVDQAP EGAKPNGAAQ PGASGGRVFA
160 170 180 190 200
SPLARRIAKQ EGIDLSAVKG SGPHGRVIQR DVQAAIEGGT AKAGAAAKPE
210 220 230 240 250
TKAPTPAADK PAPKAAPTGG APAGLSLDQV KGFYEKGSFE EVPLDGMRKT
260 270 280 290 300
IAKRLTEAMQ VAPHFYLTVD CELDALMKLR ETLNGSAGKD KDGKPLFKLS
310 320 330 340 350
VNDFVIKAMG LALTRVPAAN AVWAEDRILR FKHAEVGVAV AIDGGLFTPV
360 370 380 390 400
IRKADQKTLS TISNEMKDFA GRARAKKLKP EEYQGGVTSV SNLGMFGIKH
410 420 430 440 450
FTAVINPPQS TILAVGAGEK RVVVKDGAPA VVQAMTATLS CDHRVLDGAL
460 470
GAELIAAFKG LIENPMGMLV
Length:470
Mass (Da):48,817
Last modified:May 20, 2008 - v1
Checksum:i1623449D02EAE6EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA. Translation: ACB81067.1.
RefSeqiWP_012454787.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaiACB81067; ACB81067; Mpop_2912.
KEGGimpo:Mpop_2912.
PATRICi22563114. VBIMetPop124700_2964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA. Translation: ACB81067.1.
RefSeqiWP_012454787.1. NC_010725.1.

3D structure databases

ProteinModelPortaliB1ZEK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441620.Mpop_2912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB81067; ACB81067; Mpop_2912.
KEGGimpo:Mpop_2912.
PATRICi22563114. VBIMetPop124700_2964.

Phylogenomic databases

eggNOGiENOG4105C7S. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPHGRIQA.
OrthoDBiPOG091H0NG1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1ZEK3_METPB
AccessioniPrimary (citable) accession number: B1ZEK3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.