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B1ZDT1

- DAPF_METPB

UniProt

B1ZDT1 - DAPF_METPB

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171SubstrateUniRule annotation
    Binding sitei49 – 491SubstrateUniRule annotation
    Binding sitei69 – 691SubstrateUniRule annotation
    Active sitei78 – 781Proton donor/acceptorUniRule annotation
    Binding sitei171 – 1711SubstrateUniRule annotation
    Sitei173 – 1731Important for catalytic activityUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation
    Sitei223 – 2231Important for catalytic activityUniRule annotation
    Active sitei232 – 2321Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciMPOP441620:GHMI-2894-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Mpop_2842
    OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
    Taxonomic identifieri441620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000007136: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Diaminopimelate epimerasePRO_1000099246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 232

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi441620.Mpop_2842.

    Structurei

    3D structure databases

    ProteinModelPortaliB1ZDT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni78 – 803Substrate bindingUniRule annotation
    Regioni223 – 2242Substrate bindingUniRule annotation
    Regioni233 – 2342Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiKMRIFNN.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1ZDT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLANRRFL KMHGAGNAIV VLDLRGTSIR VAPAEARAIA ADAHSRFDQL    50
    MVVHDPVTPG TDAFMRIYNT DGSESGACGN GTRCVGYALL DDPAMARPAE 100
    NGCLTLETKA GLVAVKRVTD RSFTVDMGQP RLRWDEIPLA EPFPDTRRIE 150
    LQVGPIDDPI LHSPAAVSMG NPHAIFFVER DPDTFDLGRI GPLLEAHPIF 200
    PERANISIAQ VTSRDTIKLR VWERGAGLTL ACGTAACATV VAAARLRMIG 250
    RAARVALPGG ELSIEWRADD HVLMTGPVFL EGEGSLSPDL FAGLDG 296
    Length:296
    Mass (Da):31,724
    Last modified:May 20, 2008 - v1
    Checksum:i5CDA06C1C7121F59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB80997.1.
    RefSeqiWP_012454719.1. NC_010725.1.
    YP_001925532.1. NC_010725.1.

    Genome annotation databases

    EnsemblBacteriaiACB80997; ACB80997; Mpop_2842.
    GeneIDi6310250.
    KEGGimpo:Mpop_2842.
    PATRICi22562958. VBIMetPop124700_2888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB80997.1 .
    RefSeqi WP_012454719.1. NC_010725.1.
    YP_001925532.1. NC_010725.1.

    3D structure databases

    ProteinModelPortali B1ZDT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441620.Mpop_2842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB80997 ; ACB80997 ; Mpop_2842 .
    GeneIDi 6310250.
    KEGGi mpo:Mpop_2842.
    PATRICi 22562958. VBIMetPop124700_2888.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi KMRIFNN.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci MPOP441620:GHMI-2894-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marx C., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-705 / NCIMB 13946 / BJ001.

    Entry informationi

    Entry nameiDAPF_METPB
    AccessioniPrimary (citable) accession number: B1ZDT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3