UniProtKB - B1ZAD8 (B1ZAD8_METPB)
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Protein
Pantothenate kinase
Gene
coaA
Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Functioni
Catalytic activityi
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotationSAAS annotation
: coenzyme A biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotationSAAS annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Pantothenate kinase (coaA)
- Coenzyme A biosynthesis bifunctional protein CoaBC (Mpop_4399)
- Coenzyme A biosynthesis bifunctional protein CoaBC (Mpop_4399)
- Phosphopantetheine adenylyltransferase (coaD)
- Dephospho-CoA kinase (coaE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 115 – 122 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- pantothenate kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- coenzyme A biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | KinaseUniRule annotationSAAS annotationImported, Transferase |
Biological process | Coenzyme A biosynthesisUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00241; UER00352. |
Names & Taxonomyi
Protein namesi | Recommended name: Pantothenate kinaseUniRule annotationSAAS annotation (EC:2.7.1.33UniRule annotationSAAS annotation)Alternative name(s): Pantothenic acid kinaseUniRule annotation |
Gene namesi | Name:coaAUniRule annotation Ordered Locus Names:Mpop_2485Imported |
Organismi | Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported |
Taxonomic identifieri | 441620 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotationSAAS annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 254 | PRKInterPro annotationAdd BLAST | 145 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105CS9. Bacteria. COG1072. LUCA. |
HOGENOMi | HOG000248571. |
KOi | K00867. |
OMAi | LMQRKGF. |
OrthoDBi | POG091H073G. |
Family and domain databases
CDDi | cd02025. PanK. 1 hit. |
HAMAPi | MF_00215. Pantothen_kinase_1. 1 hit. |
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR004566. PanK. IPR006083. PRK/URK. |
PANTHERi | PTHR10285:SF7. PTHR10285:SF7. 1 hit. |
Pfami | View protein in Pfam PF00485. PRK. 1 hit. |
PIRSFi | PIRSF000545. Pantothenate_kin. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR00554. panK_bact. 1 hit. |
i Sequence
Sequence statusi: Complete.
B1ZAD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGAPIPSAG IEPEERQNPV TGQGPSRLSP YRIFSRDEWA QLRADTPLTL
60 70 80 90 100
TAEDIGRLQS LNDPISIEEV VAIYLPLSRL LSLYVAATQG LFKATQRFLL
110 120 130 140 150
AEHDAKVPYI IGLAGSVAVG KSTTARVLKA LLARWPNTPK VDLITTDGFL
160 170 180 190 200
HPNAELQRMG AMERKGFPES YDSAALLRFL ADIKAGHKHV AAPVYSHLVY
210 220 230 240 250
DVVPGEEQVI ESPDILIVEG LNVLQPARLP RDGTAIPFVS DFFDFSIYLD
260 270 280 290 300
GHEDDLHRWY VNRFLRLRQT AFRDPLSYFR KYAEVTEGEA LDIADRLWTT
310 320 330
INLPNLRDNI LPTRQRASLI LAKGPSHRIE SVALRRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001029 Genomic DNA. Translation: ACB80646.1. |
RefSeqi | WP_012454376.1. NC_010725.1. |
Genome annotation databases
EnsemblBacteriai | ACB80646; ACB80646; Mpop_2485. |
GeneIDi | 32087256. |
KEGGi | mpo:Mpop_2485. |
Similar proteinsi
Entry informationi
Entry namei | B1ZAD8_METPB | |
Accessioni | B1ZAD8Primary (citable) accession number: B1ZAD8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | March 28, 2018 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |