coaA

Functionⁱ

Catalytic activityⁱ

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotationSAAS annotation

Pathwayⁱ: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Pantothenate kinase (coaA)
no protein annotated in this organism
no protein annotated in this organism
Phosphopantetheine adenylyltransferase (coaD)
Dephospho-CoA kinase (coaE)

This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	115 – 122	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-HAMAP
pantothenate kinase activity Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

coenzyme A biosynthetic process Source: UniProtKB-HAMAP

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseUniRule annotationSAAS annotationImported, Transferase
Biological process	Coenzyme A biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00241; UER00352.

UniPathwayⁱ

UPA00241; UER00352.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pantothenate kinaseUniRule annotationSAAS annotation (EC:2.7.1.33UniRule annotationSAAS annotation) Alternative name(s): Pantothenic acid kinaseUniRule annotation
Gene namesⁱ	Name:coaAUniRule annotation Ordered Locus Names:Mpop_2485Imported
Organismⁱ	Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifierⁱ	441620 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › Methylobacterium populi
Proteomesⁱ	UP000007136 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00215
- RuleBase:RU003530
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00765478

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	441620.Mpop_2485.

STRINGⁱ

441620.Mpop_2485.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1ZAD8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	110 – 254	PRKInterPro annotationAdd BLAST		145

Sequence similaritiesⁱ

Belongs to the prokaryotic pantothenate kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CS9. Bacteria. COG1072. LUCA.
HOGENOMⁱ	HOG000248571.
KEGG Orthology (KO) More...KOⁱ	K00867.
OMAⁱ	LMQRKGF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H073G.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02025. PanK. 1 hit.
HAMAPⁱ	MF_00215. Pantothen_kinase_1. 1 hit.
InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR004566. PanK. IPR006083. PRK/URK.
PANTHERⁱ	PTHR10285:SF85. PTHR10285:SF85. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00485. PRK. 1 hit.
PIRSFⁱ	PIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00554. panK_bact. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B1ZAD8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIGAPIPSAG IEPEERQNPV TGQGPSRLSP YRIFSRDEWA QLRADTPLTL 
        60         70         80         90        100
TAEDIGRLQS LNDPISIEEV VAIYLPLSRL LSLYVAATQG LFKATQRFLL 
       110        120        130        140        150
AEHDAKVPYI IGLAGSVAVG KSTTARVLKA LLARWPNTPK VDLITTDGFL 
       160        170        180        190        200
HPNAELQRMG AMERKGFPES YDSAALLRFL ADIKAGHKHV AAPVYSHLVY 
       210        220        230        240        250
DVVPGEEQVI ESPDILIVEG LNVLQPARLP RDGTAIPFVS DFFDFSIYLD 
       260        270        280        290        300
GHEDDLHRWY VNRFLRLRQT AFRDPLSYFR KYAEVTEGEA LDIADRLWTT 
       310        320        330 
INLPNLRDNI LPTRQRASLI LAKGPSHRIE SVALRRL

Length:337

Mass (Da):37,710

Last modified:May 20, 2008 - v1

Checksum:ⁱFBFEC56CDF4D6776

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001029 Genomic DNA. Translation: ACB80646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012454376.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACB80646; ACB80646; Mpop_2485.
GeneIDⁱ	32087256.
KEGGⁱ	mpo:Mpop_2485.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001029 Genomic DNA. Translation: ACB80646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012454376.1. NC_010725.1.

3D structure databases

ProteinModelPortalⁱ	B1ZAD8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	441620.Mpop_2485.

STRINGⁱ

441620.Mpop_2485.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACB80646; ACB80646; Mpop_2485.
GeneIDⁱ	32087256.
KEGGⁱ	mpo:Mpop_2485.

Phylogenomic databases

eggNOGⁱ	ENOG4105CS9. Bacteria. COG1072. LUCA.
HOGENOMⁱ	HOG000248571.
KEGG Orthology (KO) More...KOⁱ	K00867.
OMAⁱ	LMQRKGF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H073G.

Enzyme and pathway databases

UniPathwayⁱ	UPA00241; UER00352.

UniPathwayⁱ

UPA00241; UER00352.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02025. PanK. 1 hit.
HAMAPⁱ	MF_00215. Pantothen_kinase_1. 1 hit.
InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR004566. PanK. IPR006083. PRK/URK.
PANTHERⁱ	PTHR10285:SF85. PTHR10285:SF85. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00485. PRK. 1 hit.
PIRSFⁱ	PIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00554. panK_bact. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1ZAD8_METPB
Accessionⁱ	B1ZAD8Primary (citable) accession number: B1ZAD8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 20, 2008
	Last sequence update:	May 20, 2008
	Last modified:	July 5, 2017
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1ZAD8 (B1ZAD8_METPB)

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Pantothenate kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme A biosynthesis

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: coenzyme A biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ