B1ZA90 (B1ZA90_METPB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase HAMAP MF_01374
EC=3.1.2.6 HAMAP MF_01374

Alternative name(s):
Glyoxalase II HAMAP MF_01374

Gene names

Name:	gloB HAMAP MF_01374
Ordered Locus Names:	Mpop_2438

Organism

Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001) [Complete proteome] [HAMAP]

Taxonomic identifier

441620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374 SAAS SAAS017782
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374 SAAS SAAS017782
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374 SAAS SAAS017782
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374 SAAS SAAS017782
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP MF_01374

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01374 SAAS SAAS017782 Zinc HAMAP MF_01374 SAAS SAAS017782
Molecular function	Hydrolase HAMAP MF_01374 SAAS SAAS017782 EMBL ACB80600.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	59	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	61	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	63	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	64	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	117	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	136	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	136	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	174	1	Zinc 2 By similarity HAMAP MF_01374

Sequences

	Sequence		Length	Mass (Da)
	B1ZA90 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: E1D3756494A97249	FASTA	259	27,640
	10 20 30 40 50 60 MTRAAPELRT FLCRSDNIGV LIRDPASGAC AAIDVPEAGP VLAALDAEGW TLTDILVTHR 70 80 90 100 110 120 HGDHIEGIPE VVERTGARVT APEKARAAVP GAARYVKEGD TVTVGGLSAQ VWETPGHCAD 130 140 150 160 170 180 HVTYHFADAG VAFAGDTLFT LGCGRVMEAE PATLWRSLKR FLALPDATAV YSGHDYVLSN 190 200 210 220 230 240 GRFALAADPD NADLKERVAQ AERLAQEGRF LIPSTIGEEK ATNPFLRVSE PALARSAGLE 250 PGSDPEAVFT ALRAWKNRF

References

[1]

"Complete sequence of chromosome of Methylobacterium populi BJ001." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Marx C., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-705 / NCIMB 13946 / BJ001.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001029 Genomic DNA. Translation: ACB80600.1.
RefSeq	YP_001925135.1. NC_010725.1.
3D structure databases
ProteinModelPortal	B1ZA90.
ModBase	Search...
Protein-protein interaction databases
STRING	B1ZA90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6308789.
GenomeReviews	Gene locus Mpop_2438 in contig CP001029_GR.
KEGG	mpo:Mpop_2438.
PATRIC	22562162. VBIMetPop124700_2492.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG753931.
OMA	IGCGRVF.
ProtClustDB	CLSK2331183.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1ZA90_METPB

Accession

Primary (citable) accession number: B1ZA90

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)