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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Mpop_4660), Pyruvate kinase (Mpop_2866)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei203ATPUniRule annotation1
Binding sitei325ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi355 – 358ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Mpop_2324
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000007136 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002033411 – 400Phosphoglycerate kinaseAdd BLAST400

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi441620.Mpop_2324

Structurei

3D structure databases

ProteinModelPortaliB1Z980
SMRiB1Z980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 25Substrate bindingUniRule annotation3
Regioni61 – 64Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1Z980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFRTLDDA GPLQGKRVLL RVDLNVPMEG GRVTDATRIE RVVPTIREIA
60 70 80 90 100
EAGGRVILLA HFGRPKGKPE PKDSLKPILP TLSEKLGRPV AFGEDCVGEA
110 120 130 140 150
AAKAVAALKD GDVLLLENTR YHAGEEKNAP EFAQALAANG DLYVNEAFSA
160 170 180 190 200
AHRAHASTEG LARLLPAYAG RLMQAELDAL TKGLEAPARP VIAIVGGAKV
210 220 230 240 250
STKIDLLENL VAKVDMLVIG GGMANTFLHA QGKDVGKSLC EKDLAETAQR
260 270 280 290 300
ILAAAKEKNC TIILPADALV AREFKANAEN ETVTVDAVPS DAMILDVGAS
310 320 330 340 350
SIATIDGAID EARTLVWNGP LGAFELTPFD TGTVAVAQHA ARRTRAGQLV
360 370 380 390 400
SVAGGGDTVA ALNHAGVGED FSYVSTAGGA FLEWLEGKEL PGVEALRAKA
Length:400
Mass (Da):41,844
Last modified:May 20, 2008 - v1
Checksum:iAAD2E8EFE84CBEE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001029 Genomic DNA Translation: ACB80486.1
RefSeqiWP_012454219.1, NC_010725.1

Genome annotation databases

EnsemblBacteriaiACB80486; ACB80486; Mpop_2324
GeneIDi32085989
KEGGimpo:Mpop_2324

Similar proteinsi

Entry informationi

Entry nameiPGK_METPB
AccessioniPrimary (citable) accession number: B1Z980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health