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B1Z8W8

- B1Z8W8_METPB

UniProt

B1Z8W8 - B1Z8W8_METPB

Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotationSAAS annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi121 – 1277ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
    3. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPOP441620:GHMI-5244-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
    Alternative name(s):
    D-glutamic acid-adding enzymeUniRule annotation
    UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
    Gene namesi
    Name:murDUniRule annotation
    Ordered Locus Names:Mpop_5174Imported
    OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
    Taxonomic identifieri441620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000007136: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131 PotentialImportedAdd
    BLAST
    Chaini32 – 455424 PotentialImportedPRO_5000334233Add
    BLAST

    Proteomic databases

    PRIDEiB1Z8W8.

    Interactioni

    Protein-protein interaction databases

    STRINGi441620.Mpop_5174.

    Structurei

    3D structure databases

    ProteinModelPortaliB1Z8W8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG0771.
    HOGENOMiHOG000049428.
    KOiK01925.
    OMAiYCFGQDG.
    OrthoDBiEOG6HXJ9C.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00639. MurD.
    InterProiIPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR016040. NAD(P)-bd_dom.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view]
    PfamiPF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01087. murD. 1 hit.
    PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B1Z8W8-1 [UniParc]FASTAAdd to Basket

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    MTPATTFAGQ KLALFGLGGS GLATVRSLLA GGADVLAWDD NAGSRDRARE    50
    QGITVTDLND ADWSGFSALV LAPGVPLTHP EPHWTVGLAQ QAGIPIIGDI 100
    EIFCRERAAL APEAPFVAIT GTNGKSTTTA LTAHLLRHAG RDVQMGGNIG 150
    TAVLSLAPPA ENRVHVVELS SFQIDLTPSL DPSVGILLNL TPDHLDRHGT 200
    MENYAAIKER LVAGSDLAVI GVDDAYCAAI AGRRRGERIR LHVEGHGDAA 250
    GDYVCRAGAV RGPDGAVIAE ISGIQSLLGE HNLQNAAAAV AAALRLGLTG 300
    AEIAAGLKSF PGLAHRMEPL RRIGPTLFVN DSKATNADST EKALLAFRDI 350
    HWIVGGKAKE GGIEPLAPLF DRVAHAYLIG ASSDAFAATL DGRLPFTRCD 400
    TLEAATAAAA QAARASATDA PVVLLSPACA SYDQFPNFEV RGDRFRALVA 450
    ALPEA 455
    Length:455
    Mass (Da):47,273
    Last modified:May 20, 2008 - v1
    Checksum:iF0D74AD6D6C13473
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB83268.1.
    RefSeqiWP_012456864.1. NC_010725.1.
    YP_001927803.1. NC_010725.1.

    Genome annotation databases

    EnsemblBacteriaiACB83268; ACB83268; Mpop_5174.
    GeneIDi6312528.
    KEGGimpo:Mpop_5174.
    PATRICi22567614. VBIMetPop124700_5198.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001029 Genomic DNA. Translation: ACB83268.1 .
    RefSeqi WP_012456864.1. NC_010725.1.
    YP_001927803.1. NC_010725.1.

    3D structure databases

    ProteinModelPortali B1Z8W8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441620.Mpop_5174.

    Proteomic databases

    PRIDEi B1Z8W8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB83268 ; ACB83268 ; Mpop_5174 .
    GeneIDi 6312528.
    KEGGi mpo:Mpop_5174.
    PATRICi 22567614. VBIMetPop124700_5198.

    Phylogenomic databases

    eggNOGi COG0771.
    HOGENOMi HOG000049428.
    KOi K01925.
    OMAi YCFGQDG.
    OrthoDBi EOG6HXJ9C.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci MPOP441620:GHMI-5244-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00639. MurD.
    InterProi IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR016040. NAD(P)-bd_dom.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view ]
    Pfami PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01087. murD. 1 hit.
    PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marx C., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-705 / NCIMB 13946 / BJ001Imported.

    Entry informationi

    Entry nameiB1Z8W8_METPB
    AccessioniPrimary (citable) accession number: B1Z8W8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3