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B1Z8W8

- B1Z8W8_METPB

UniProt

B1Z8W8 - B1Z8W8_METPB

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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene
murD, Mpop_5174
Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotationSAAS annotations

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1277ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
  3. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPOP441620:GHMI-5244-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:Mpop_5174Imported
OrganismiMethylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)Imported
Taxonomic identifieri441620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000007136: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 PredictedImportedAdd
BLAST
Chaini32 – 455424 PredictedImportedPRO_5000334233Add
BLAST

Proteomic databases

PRIDEiB1Z8W8.

Interactioni

Protein-protein interaction databases

STRINGi441620.Mpop_5174.

Structurei

3D structure databases

ProteinModelPortaliB1Z8W8.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG0771.
HOGENOMiHOG000049428.
KOiK01925.
OMAiYCFGQDG.
OrthoDBiEOG6HXJ9C.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD.
InterProiIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1Z8W8-1 [UniParc]FASTAAdd to Basket

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MTPATTFAGQ KLALFGLGGS GLATVRSLLA GGADVLAWDD NAGSRDRARE    50
QGITVTDLND ADWSGFSALV LAPGVPLTHP EPHWTVGLAQ QAGIPIIGDI 100
EIFCRERAAL APEAPFVAIT GTNGKSTTTA LTAHLLRHAG RDVQMGGNIG 150
TAVLSLAPPA ENRVHVVELS SFQIDLTPSL DPSVGILLNL TPDHLDRHGT 200
MENYAAIKER LVAGSDLAVI GVDDAYCAAI AGRRRGERIR LHVEGHGDAA 250
GDYVCRAGAV RGPDGAVIAE ISGIQSLLGE HNLQNAAAAV AAALRLGLTG 300
AEIAAGLKSF PGLAHRMEPL RRIGPTLFVN DSKATNADST EKALLAFRDI 350
HWIVGGKAKE GGIEPLAPLF DRVAHAYLIG ASSDAFAATL DGRLPFTRCD 400
TLEAATAAAA QAARASATDA PVVLLSPACA SYDQFPNFEV RGDRFRALVA 450
ALPEA 455
Length:455
Mass (Da):47,273
Last modified:May 20, 2008 - v1
Checksum:iF0D74AD6D6C13473
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB83268.1.
RefSeqiWP_012456864.1. NC_010725.1.
YP_001927803.1. NC_010725.1.

Genome annotation databases

EnsemblBacteriaiACB83268; ACB83268; Mpop_5174.
GeneIDi6312528.
KEGGimpo:Mpop_5174.
PATRICi22567614. VBIMetPop124700_5198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001029 Genomic DNA. Translation: ACB83268.1 .
RefSeqi WP_012456864.1. NC_010725.1.
YP_001927803.1. NC_010725.1.

3D structure databases

ProteinModelPortali B1Z8W8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441620.Mpop_5174.

Proteomic databases

PRIDEi B1Z8W8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB83268 ; ACB83268 ; Mpop_5174 .
GeneIDi 6312528.
KEGGi mpo:Mpop_5174.
PATRICi 22567614. VBIMetPop124700_5198.

Phylogenomic databases

eggNOGi COG0771.
HOGENOMi HOG000049428.
KOi K01925.
OMAi YCFGQDG.
OrthoDBi EOG6HXJ9C.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MPOP441620:GHMI-5244-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00639. MurD.
InterProi IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view ]
Pfami PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01087. murD. 1 hit.
PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methylobacterium populi BJ001."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marx C., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-705 / NCIMB 13946 / BJ001.

Entry informationi

Entry nameiB1Z8W8_METPB
AccessioniPrimary (citable) accession number: B1Z8W8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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