Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104Transition state stabilizerUniRule annotation1
Active sitei108Proton acceptorUniRule annotation1
Metal bindingi269Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAMB398577:G1GBO-5609-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:BamMC406_5625
OrganismiBurkholderia ambifaria (strain MC40-6)
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001680 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28UniRule annotationAdd BLAST28
ChainiPRO_500033400429 – 741Catalase-peroxidase 2Add BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki107 ↔ 228Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)UniRule annotation
Cross-linki228 ↔ 254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB1Z5M2

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1Z5M2
SMRiB1Z5M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1Z5M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKRIGKSV VAALAIIAMS AGTVAAWADG APRTNDFWWP ERLDLSPLRQ
60 70 80 90 100
HDVESNPYGK DFDYAQAFNK LDIEAVKKDI RATLTTSQDW WPADYGNYGP
110 120 130 140 150
FFIRMAWHGA GTYRTYDGRG GAGGAQQRFE PLNSWPDNAN LDKARRLLWP
160 170 180 190 200
IKKKYGQNIS WGDLMVLTGN VALESMGFQT FGFGGGREDD WQSDLVYWGA
210 220 230 240 250
GTKFMSDNRD KNGKLEKPLA ATQMGLIYVN PEGPNGNPDP VAAAKDIREA
260 270 280 290 300
FGRMAMNDEE TLALIAGGHT FGKAHGAASP DKCVGAAPAG AGVEAQGLGW
310 320 330 340 350
ANKCGTGKGA DTITSGLEGA WSVDPVHFTM QYLDNLLEHD WVLTKSPAGA
360 370 380 390 400
HQWMPKDAQD IVPDAHDPSK RHPLMMFTTD IALKVDPAYS AIAKRFQAHP
410 420 430 440 450
EEFKLAFAKA WFKLTHRDLG PKARYLGKDV PKVDLIWQDP LPVAGYQMIG
460 470 480 490 500
DADIAELKRR ILASGVPKSE LIKTAWASAA SFRATDYRGG ANGARIRLAP
510 520 530 540 550
ENAWAVNDPA SLSKVLKSLE DIQSGFNRNR TDGKQVSLAD LIVLGGSAAV
560 570 580 590 600
EDAARKAGYD VKVPFSPGRV DATQAQTDVA SFAVLEPTSD GFRNYYRKSN
610 620 630 640 650
ERSPAELMVD RASKLDLSVP EMTVLVGGLR ALDANAGHSR LGVLTNRPGT
660 670 680 690 700
LSNDFFVNLL DMSTQWTKSS SADGTYEGRD RKTGALKWTA SPVDLVFGSS
710 720 730 740
SELRAVAEVY ASDDAHEKFV RDFVHAWTKV MNLDRFDLKR S
Length:741
Mass (Da):80,998
Last modified:May 20, 2008 - v1
Checksum:i67DA44587234D352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001027 Genomic DNA Translation: ACB68068.1
RefSeqiWP_012372008.1, NC_010557.1

Genome annotation databases

EnsemblBacteriaiACB68068; ACB68068; BamMC406_5625
KEGGibac:BamMC406_5625

Similar proteinsi

Entry informationi

Entry nameiKATG2_BURA4
AccessioniPrimary (citable) accession number: B1Z5M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health