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B1Z3L5

- B1Z3L5_BURA4

UniProt

B1Z3L5 - B1Z3L5_BURA4

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Protein
Acetyl-coenzyme A synthetase
Gene
acsA, BamMC406_5891
Organism
Burkholderia ambifaria (strain MC40-6)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei321 – 3211Coenzyme A By similarityUniRule annotation
Binding sitei401 – 4011Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei516 – 5161Substrate By similarityUniRule annotation
Binding sitei532 – 5321Substrate By similarityUniRule annotation
Active sitei534 – 5341 By similarityUniRule annotation
Binding sitei540 – 5401Coenzyme A By similarityUniRule annotation
Binding sitei543 – 5431Substrate By similarityUniRule annotation
Metal bindingi554 – 5541Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi556 – 5561Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi559 – 5591Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei604 – 6041Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAMB398577:GH38-5979-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:BamMC406_5891Imported
OrganismiBurkholderia ambifaria (strain MC40-6)Imported
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001680: Chromosome 3

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi398577.BamMC406_5891.

Structurei

3D structure databases

ProteinModelPortaliB1Z3L5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni425 – 4306Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiRRIFEPT.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1Z3L5-1 [UniParc]FASTAAdd to Basket

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MENTLTAIVS ILQERRIFEP TADTRERATI SGMPAYQALA AEAERDYEGF    50
WARLAREGLS WHKPFTKVLD ESDAPFYKWF DDGELNASYN CLDRHVEAGN 100
GERVAVIFEA DDGTVTRVTY ADLLARVSRF ANALKKRGIA KGDRVVIYMP 150
MSIEGIVAMQ ACARIGATHS VVFGGFSAKS LNERLVDVGA VALITADEQA 200
RGGKTLPLKS IADEAIAMGG CEAVKSVIVY RRTGGKVDWH AGRDLWMHEL 250
AHAESDTCAP EWVGAEHPLF ILYTSGSTGK PKGVQHSTGG YLLWAAQTMK 300
WTFDWKPTDV FWCTADIGWV TGHTYITYGP LACGGTQVVF EGVPTYPDAG 350
RFWKMIADHK VTVFYTAPTA IRSLIKAAEA DDKVHPKSYD LSSLRIIGTV 400
GEPINPEAWM WYHKHVGQER CPIVDTWWQT ETGGHMITPL PGATPTVPGS 450
CTLPLPGIMA AVVDETGQDV PNGQGGILVV KRPWPAMIRT IWGDPERFKK 500
SYYPEELGGR LYLAGDGTVR DKDTGYFTIM GRIDDVLNVS GHRLGTMEIE 550
SALVSHELVA EAAVVGRPDD TTGEAVVAFV VLKRSRPEGE EAAALAKTLR 600
DWVGKQIGPI AKPKDIRFGD NLPKTRSGKI MRRLLRSLAK GEAITQDTST 650
LENPAILDQL GQSL 664
Length:664
Mass (Da):72,777
Last modified:May 20, 2008 - v1
Checksum:i208A8B2F4243E6FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001027 Genomic DNA. Translation: ACB68328.1.
RefSeqiYP_001815881.1. NC_010557.1.

Genome annotation databases

EnsemblBacteriaiACB68328; ACB68328; BamMC406_5891.
GeneIDi6182474.
KEGGibac:BamMC406_5891.
PATRICi19042153. VBIBurAmb82852_6352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001027 Genomic DNA. Translation: ACB68328.1 .
RefSeqi YP_001815881.1. NC_010557.1.

3D structure databases

ProteinModelPortali B1Z3L5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398577.BamMC406_5891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB68328 ; ACB68328 ; BamMC406_5891 .
GeneIDi 6182474.
KEGGi bac:BamMC406_5891.
PATRICi 19042153. VBIBurAmb82852_6352.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi RRIFEPT.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci BAMB398577:GH38-5979-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 3 of Burkholderia ambifaria MC40-6."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
    , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC40-6.

Entry informationi

Entry nameiB1Z3L5_BURA4
AccessioniPrimary (citable) accession number: B1Z3L5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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