Skip Header

Contribute Send feedback
Read comments (?) or add your own

B1Z2A5 (B1Z2A5_BURA4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH2 HAMAP MF_00191
Ordered Locus Names:BamMC406_5423
OrganismBurkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]
Taxonomic identifier398577 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B1Z2A5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: A4B24F8BC4A766C0

FASTA31333,706
        10         20         30         40         50         60 
MRVILAQPRG FCAGVVRAIE IVDRALQQHG APVYVRHEIV HNRHVVENLR NKGARFVEEL 

        70         80         90        100        110        120 
DEVPHGAVAI FSAHGVAQTV ERDAETRGLD VLDATCPLVT KVHVQGRQYV AAGRRLILIG 

       130        140        150        160        170        180 
HAGHPEVEGT IGQIPAEVIL VQSEAEVDTL TLPVDTPVAY VTQTTLSVDD TRGIIEALQR 

       190        200        210        220        230        240 
RFTDIVGPDT RDICYATQNR QAAVRELSGQ VDVLLVVGAT NSSNSNRLRE IGTESGVPSY 

       250        260        270        280        290        300 
LVADGSEVKP EWFAGVQTVG LTAGASAPEE MVEDVIGALR ALGPVDVTTM AGREEKVEFK 

       310 
LPAKLTQAVA REV

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001026 Genomic DNA. Translation: ACB67867.1.
RefSeqYP_001812083.1. NC_010552.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB1Z2A5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6180159.
GenomeReviewsGene locus BamMC406_5423 in contig CP001026_GR.
KEGGbac:BamMC406_5423.
PATRIC19040711. VBIBurAmb82852_5637.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1Z2A5_BURA4
AccessionPrimary (citable) accession number: B1Z2A5
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info