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B1Z1G3

- GCH4_BURA4

UniProt

B1Z1G3 - GCH4_BURA4

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBAMB398577:GH38-3852-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:BamMC406_3777
    OrganismiBurkholderia ambifaria (strain MC40-6)
    Taxonomic identifieri398577 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000001680: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000372021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398577.BamMC406_3777.

    Structurei

    3D structure databases

    ProteinModelPortaliB1Z1G3.
    SMRiB1Z1G3. Positions 21-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1Z1G3-1 [UniParc]FASTAAdd to Basket

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    MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVRT ESGDVQPTVG    50
    VWNLDVHLPA DQKGTHMSRF VALLEESREP LTVERFRAML ASMLVRLEAE 100
    AGRIEVTFPY FVNKTAPVSG VQSLLDYEVT LAGESRNGET RLFLKVLVPV 150
    TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DLPVEALIRI AEEEASCELW 200
    GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLDADERVV AYVLEAENFE 250
    SIHNHSAYAL IERDKRHAA 269
    Length:269
    Mass (Da):30,259
    Last modified:May 20, 2008 - v1
    Checksum:iFA7DC1BBA88E69C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001026 Genomic DNA. Translation: ACB66244.1.
    RefSeqiYP_001810460.1. NC_010552.1.

    Genome annotation databases

    EnsemblBacteriaiACB66244; ACB66244; BamMC406_3777.
    GeneIDi6181250.
    KEGGibac:BamMC406_3777.
    PATRICi19037209. VBIBurAmb82852_3897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001026 Genomic DNA. Translation: ACB66244.1 .
    RefSeqi YP_001810460.1. NC_010552.1.

    3D structure databases

    ProteinModelPortali B1Z1G3.
    SMRi B1Z1G3. Positions 21-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398577.BamMC406_3777.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB66244 ; ACB66244 ; BamMC406_3777 .
    GeneIDi 6181250.
    KEGGi bac:BamMC406_3777.
    PATRICi 19037209. VBIBurAmb82852_3897.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BAMB398577:GH38-3852-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
      , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC40-6.

    Entry informationi

    Entry nameiGCH4_BURA4
    AccessioniPrimary (citable) accession number: B1Z1G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3