B1Z151 (KHSE_BURA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BamMC406_3764

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Homoserine kinase HAMAP MF_00301		PRO_1000115425

Sequences

	Sequence		Length	Mass (Da)
	B1Z151 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: FFD00F871FC7B120	FASTA	332	37,165
	10 20 30 40 50 60 MAVFTAVSDS DLAQWMRHYE LGDVLAFRGI PSGIENSNFF LTTTRGEYVL TIFEKLTAEQ 70 80 90 100 110 120 LPFYLDLMRH LASHGVPVPD PIPRDDGALF GLLHGKPAAI VTKLDGAAEL APGIEHCIEV 130 140 150 160 170 180 GQMLARLHLA GRDYARYQPN LRSLPWWQEN VPAIVPFVSD AQRALLEGEL AHQAAFFASD 190 200 210 220 230 240 DYAALPSGPC HCDLFRDNVL FAHAAPGTGH DVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGVLDV ARADALLRAY QTVRPFTAAE RRHWSDMLRA GAYRFWVSRL YDFYLPRAAE 310 320 330 MLKPHDPGHF ERILRERIAH TPALPETHTA CN

References

[1]

"Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC40-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001026 Genomic DNA. Translation: ACB66231.1.
RefSeq	YP_001810447.1. NC_010552.1.
3D structure databases
ProteinModelPortal	B1Z151.
ModBase	Search...
Protein-protein interaction databases
STRING	B1Z151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6180867.
GenomeReviews	Gene locus BamMC406_3764 in contig CP001026_GR.
KEGG	bac:BamMC406_3764.
PATRIC	19037181. VBIBurAmb82852_3883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BAMB398577:BAMMC406_3764-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURA4

Accession

Primary (citable) accession number: B1Z151

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program