B1Z0T5 (B1Z0T5_BURA4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	BamMC406_5192

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 SAAS SAAS022893
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	134 – 138	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	74	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B1Z0T5 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 4CA3028C3B283EAE	FASTA	284	30,306
	10 20 30 40 50 60 MSRPSFLIGL IGQGIGGSLS PAMHEEEGFR QGFGYVYRRI DLDALGLTVD ALPQLLEAAQ 70 80 90 100 110 120 RMGYNGLNIT HPCKQRVIEH LDALSDDARA LGAVNTVLFK DGKRIGHNTD WSGFAKSFRR 130 140 150 160 170 180 GLPDASLERV VQLGAGGAGA AVAHAALQMG AAELTIFDVD GTRADTLASE LQQRFPVARV 190 200 210 220 230 240 TPGSDRAAAM RAATGLIHAT PTGMTKHPGL PLPAELLHAG MWVADIVYFP LETELIRAAR 250 260 270 280 AAGCATLPGG GMAVYQAVDA FEIFTGRTPD DERMFEHFQS LVAR

References

[1]

"Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001026 Genomic DNA. Translation: ACB67637.1.
RefSeq	YP_001811853.1. NC_010552.1.
3D structure databases
ProteinModelPortal	B1Z0T5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1Z0T5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6179880.
GenomeReviews	Gene locus BamMC406_5192 in contig CP001026_GR.
KEGG	bac:BamMC406_5192.
PATRIC	19040233. VBIBurAmb82852_5398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1Z0T5_BURA4

Accession

Primary (citable) accession number: B1Z0T5

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)