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B1Z034

- BETA_BURA4

UniProt

B1Z034 - BETA_BURA4

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, BamMC406_5037
Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei474 – 4741 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBAMB398577:GH38-5115-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:BamMC406_5037
OrganismiBurkholderia ambifaria (strain MC40-6)
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001680: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000133320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398577.BamMC406_5037.

Structurei

3D structure databases

ProteinModelPortaliB1Z034.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1Z034-1 [UniParc]FASTAAdd to Basket

« Hide

MTTREYDYII CGAGSAGNVL ATRLTEDPNV TVLLLEAGGP DYRFDFRTQM    50
PAALAYPLQG RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI 100
RGNALDYDNW STHKGLENWT YLDCLPYFKK AETRDVGPND YHGGDGPVSV 150
TTSKPGVNPL FEAMVDAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTPKGRR 200
ASTARGYLDQ AKGRPNLEIV THALADRILF DGKRASGVTY LRGSERANAH 250
ARREVLVCSG AIASPQLLQR SGVGPGAWLK ELDIPIVLDL PGVGQNLQDH 300
LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI 350
RTRDDDPWPN IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL 400
RSRDPNAHPS ILFNYMAEAL DWREFRDAIR ATREIMRQPA LDRYRGRELN 450
PGADCKSDKE LDTFVRSRAE TAFHPSCSCK MGYDDMAVVD EEGRVHGLEG 500
LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRQPLAR VDVPYFVANG 550
AMARNVAKAV RQPETV 566
Length:566
Mass (Da):62,930
Last modified:May 20, 2008 - v1
Checksum:i258FEBF5A8D8D1CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001026 Genomic DNA. Translation: ACB67483.1.
RefSeqiYP_001811699.1. NC_010552.1.

Genome annotation databases

EnsemblBacteriaiACB67483; ACB67483; BamMC406_5037.
GeneIDi6179679.
KEGGibac:BamMC406_5037.
PATRICi19039886. VBIBurAmb82852_5230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001026 Genomic DNA. Translation: ACB67483.1 .
RefSeqi YP_001811699.1. NC_010552.1.

3D structure databases

ProteinModelPortali B1Z034.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398577.BamMC406_5037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB67483 ; ACB67483 ; BamMC406_5037 .
GeneIDi 6179679.
KEGGi bac:BamMC406_5037.
PATRICi 19039886. VBIBurAmb82852_5230.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BAMB398577:GH38-5115-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
    , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC40-6.

Entry informationi

Entry nameiBETA_BURA4
AccessioniPrimary (citable) accession number: B1Z034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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