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Reviewed, UniProtKB/Swiss-Prot B1YWB2 (GLPK_BURA4)

Last modified November 3, 2009. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: BamMC406_2603
OrganismBurkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]
Taxonomic identifier398577 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glycerol kinase HAMAP MF_00186
PRO_1000098719

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1351Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
B1YWB2-1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 0320E145982D3BEA

FASTA50054,665
        10         20         30         40         50         60 
MQDQYILALD QGTTSSRAML FDRQGNIVSI AQKEFEQIYP QPGWVEHDPQ EIWSTQAGVA 

        70         80         90        100        110        120 
AEAVTRTGLN GTSIAAIGIT NQRETTIVWD RETGQPVYNA IVWQDRRTAD FCDSLKKQGL 

       130        140        150        160        170        180 
EAKVRAKTGL PIDSYFSATK IRWILDNVPG ARDKARQGKL AFGTVDSWLV WNFTKHELHV 

       190        200        210        220        230        240 
TDVTNASRTM LFNIHTREWD SELLELLDIP RSMLPDVKAS SEIYGHTKTT VFASKIPLAG 

       250        260        270        280        290        300 
IAGDQHAALF GQMCTTSGMV KNTYGTGCFL MMNTGDKPIE SKNNLVTTIA WQIGDDVQYA 

       310        320        330        340        350        360 
LEGSIFIAGA VVQWLRDGVG IIKTAAEIEA LAASVPHTDG VYLVPAFAGL GAPHWNARAR 

       370        380        390        400        410        420 
GSVFGVTRGT TAAHLARAAL DSIAYQSLDV LAAMEADSGI SIGELRVDGG ASANDLLMQF 

       430        440        450        460        470        480 
QADLLGVDAV RPQITETTAL GAAYLAGLAI GYWKNLDEVR SQWQLDRRFS PSMPKEQVEQ 

       490        500 
RMAGWQRAVR AAKAWADDTQ

« Hide

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References

[1]"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001025 Genomic DNA. Translation: ACB65080.1.
RefSeqYP_001809296.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6176136.
KEGGbac:BamMC406_2603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIAQREFT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_BURA4
AccessionPrimary (citable) accession number: B1YWB2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents