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Protein

Glycerol kinase

Gene

glpK

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei309ATP; via carbonyl oxygenUniRule annotation1
Binding sitei313ATP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi410 – 414ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAMB398577:G1GBO-2636-MONOMER
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:BamMC406_2603
OrganismiBurkholderia ambifaria (strain MC40-6)
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000987191 – 500Glycerol kinaseAdd BLAST500

Proteomic databases

PRIDEiB1YWB2

Structurei

3D structure databases

ProteinModelPortaliB1YWB2
SMRiB1YWB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingUniRule annotation2
Regioni244 – 245Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ
OrthoDBiPOG091H02FA

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1YWB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDQYILALD QGTTSSRAML FDRQGNIVSI AQKEFEQIYP QPGWVEHDPQ
60 70 80 90 100
EIWSTQAGVA AEAVTRTGLN GTSIAAIGIT NQRETTIVWD RETGQPVYNA
110 120 130 140 150
IVWQDRRTAD FCDSLKKQGL EAKVRAKTGL PIDSYFSATK IRWILDNVPG
160 170 180 190 200
ARDKARQGKL AFGTVDSWLV WNFTKHELHV TDVTNASRTM LFNIHTREWD
210 220 230 240 250
SELLELLDIP RSMLPDVKAS SEIYGHTKTT VFASKIPLAG IAGDQHAALF
260 270 280 290 300
GQMCTTSGMV KNTYGTGCFL MMNTGDKPIE SKNNLVTTIA WQIGDDVQYA
310 320 330 340 350
LEGSIFIAGA VVQWLRDGVG IIKTAAEIEA LAASVPHTDG VYLVPAFAGL
360 370 380 390 400
GAPHWNARAR GSVFGVTRGT TAAHLARAAL DSIAYQSLDV LAAMEADSGI
410 420 430 440 450
SIGELRVDGG ASANDLLMQF QADLLGVDAV RPQITETTAL GAAYLAGLAI
460 470 480 490 500
GYWKNLDEVR SQWQLDRRFS PSMPKEQVEQ RMAGWQRAVR AAKAWADDTQ
Length:500
Mass (Da):54,665
Last modified:May 20, 2008 - v1
Checksum:i0320E145982D3BEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001025 Genomic DNA Translation: ACB65080.1
RefSeqiWP_012364653.1, NC_010551.1

Genome annotation databases

EnsemblBacteriaiACB65080; ACB65080; BamMC406_2603
KEGGibac:BamMC406_2603

Similar proteinsi

Entry informationi

Entry nameiGLPK_BURA4
AccessioniPrimary (citable) accession number: B1YWB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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