B1YVH0 (KYNB_BURA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BamMC406_2496

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362099

Sequences

	Sequence		Length	Mass (Da)
	B1YVH0 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: A978C0DED6293390	FASTA	213	22,699
	10 20 30 40 50 60 MDTLWDISPP VSPATPVWPG DTPVSVERVW RMEAGSPVNV ARLTLSPHTG AHCDAPLHYD 70 80 90 100 110 120 ADGAPIGAVP LDTYLGPCRV IHCIGAAPVV RPADIEAALD GVPPRVLLRT YARASVEQWD 130 140 150 160 170 180 SGFCAVAPET VDLLAARGVK LIGIDTPSLD PQESKTMDAH HRVRAHRMAI LEGIVLDDVP 190 200 210 PGDYELIALP LKFTTLDASP VRAVLRALPG HSA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC40-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001025 Genomic DNA. Translation: ACB64974.1.
RefSeq	YP_001809190.1. NC_010551.1.
3D structure databases
ProteinModelPortal	B1YVH0.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YVH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6178576.
GenomeReviews	Gene locus BamMC406_2496 in contig CP001025_GR.
KEGG	bac:BamMC406_2496.
PATRIC	19034539. VBIBurAmb82852_2568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686791.
OMA	FERVPAN.
ProtClustDB	CLSK930430.
Enzyme and pathway databases
BioCyc	BAMB398577:BAMMC406_2496-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURA4

Accession

Primary (citable) accession number: B1YVH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program