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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAMB398577:GH38-664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:BamMC406_0642
OrganismiBurkholderia ambifaria (strain MC40-6)
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Catalase-peroxidase 1PRO_0000354731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB1YTH4.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1YTH4.
SMRiB1YTH4. Positions 16-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YTH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESKCPFN HTAAGGTSNK DWWPNQLNLN ILHRHSALSD PMDKDFDYAQ
60 70 80 90 100
AFKKLDLAAV KRDLQALMTT SQDWWPADFG HYGGLFVRMA WHSAGTYRTA
110 120 130 140 150
DGRGGAGGGQ QRFAPLNSWP DNANLDKARR LLWPIKQKYG RNISWADLLI
160 170 180 190 200
LTGNVALESM GFKTFGYAGG RADTWEPDDV YWGSEKIWLE LSGGPNSRYS
210 220 230 240 250
GDRELENPLA AVQMGLIYVN PEGPDGNPDP VAAARDIRDT FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGPA TDVGPEPEAA GIEQQGLGWK SAYASGKGHD
310 320 330 340 350
AITSGLEVTW TSTPTKWSHD FFKHLFSYEW ELTKSPAGAH QWVAKGADEV
360 370 380 390 400
IPDAFDASKK HRPTMLTTDL SLRFDPAYEK ISRRFYENPA EFADAFARAW
410 420 430 440 450
FKLTHRDMGP RARYLGPEVP AEELLWQDPI PVVDHPLIDD ADVAALKAKV
460 470 480 490 500
LASGLSVAQL VSTAWASAST FRGSDKRGGA NGARIRLAPQ KDWEVNQPAA
510 520 530 540 550
LAAVLETLEG VRKAFNDAQT GGKKVSLADL IVLAGAAGIE QAAKNAGVAV
560 570 580 590 600
TVPFAPGRMD ASQEQTDVDA MAVLEPVADG FRNYLKSAYK TPAEALLVDK
610 620 630 640 650
AQLLTLNGPE LTVLVGGLRV LGANVGDAKH GVFTDRPGTL SNDFFVNLLD
660 670 680 690 700
MGTEWKPVSA ANDVFEGRDR ATGLVKWTGT RVDLIFGSHS QLRALAEVYG
710 720
SADANEKFVR DFVAAWDKVM NLDRFDLA
Length:728
Mass (Da):79,221
Last modified:May 20, 2008 - v1
Checksum:i6E914122B42278BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001025 Genomic DNA. Translation: ACB63139.1.
RefSeqiWP_012363134.1. NC_010551.1.

Genome annotation databases

EnsemblBacteriaiACB63139; ACB63139; BamMC406_0642.
KEGGibac:BamMC406_0642.
PATRICi19030598. VBIBurAmb82852_0648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001025 Genomic DNA. Translation: ACB63139.1.
RefSeqiWP_012363134.1. NC_010551.1.

3D structure databases

ProteinModelPortaliB1YTH4.
SMRiB1YTH4. Positions 16-728.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB1YTH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB63139; ACB63139; BamMC406_0642.
KEGGibac:BamMC406_0642.
PATRICi19030598. VBIBurAmb82852_0648.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciBAMB398577:GH38-664-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
    , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC40-6.

Entry informationi

Entry nameiKATG1_BURA4
AccessioniPrimary (citable) accession number: B1YTH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.