Reviewed,
UniProtKB/Swiss-Prot B1YTE2 (PUR9_BURA4)
Last modified
February 9, 2010.
Version 14.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional purine biosynthesis protein purH Including the following 2 domains: 1- Recommended name: Phosphoribosylaminoimidazolecarboxamide formyltransferase EC=2.1.2.3 Alternative name(s): AICAR transformylase 2- Recommended name: IMP cyclohydrolase EC=3.5.4.10 Alternative name(s): Inosinicase IMP synthetase ATIC | ||||
| Gene names |
| ||||
| Organism | Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 398577 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 |
| Domain | The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP MF_00139 |
| Sequence similarities | Belongs to the purH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Hydrolase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 521 | 521 | Bifunctional purine biosynthesis protein purH HAMAP MF_00139 | PRO_1000096043 | |||
Sequences
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References
| [1] | "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. Richardson P.Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP001025 Genomic DNA. Translation: ACB63107.1. |
| RefSeq | YP_001807323.1. |
3D structure databases | |
| SMR | B1YTE2. Positions 2-521. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 6177943. |
| GenomeReviews | Gene locus BamMC406_0610 in contig CP001025_GR. |
| KEGG | bac:BamMC406_0610. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG498048. |
| OMA | VVKHVKS. |
Family and domain databases | |
| HAMAP | MF_00139. PurH. [Tree] |
| InterPro | IPR002695. AICARFT_IMPCHas. IPR013982. AICARFT_IMPCHase_bienz. IPR011607. MGS. [Graphical view] |
| PANTHER | PTHR11692. AICARFT_IMPCHas. 1 hit. |
| Pfam | PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view] |
| PIRSF | PIRSF000414. AICARFT_IMPCHas. 1 hit. |
| SMART | SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00355. purH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR9_BURA4 | ||||||||
| Accession | Primary (citable) accession number: B1YTE2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


