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B1YTA7

- SYL_BURA4

UniProt

B1YTA7 - SYL_BURA4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAMB398577:GH38-596-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BamMC406_0575
    OrganismiBurkholderia ambifaria (strain MC40-6)
    Taxonomic identifieri398577 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000001680: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_1000091296Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398577.BamMC406_0575.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YTA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1YTA7-1 [UniParc]FASTAAdd to Basket

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    MHERYVPADV EAAAQGDWRA ADAYKTREDS QKPKFYCVSM LPYPSGKLHM    50
    GHVRNYTIND VMYRYLRMNG YNTLMPMGWD AFGMPAENAA MANGVPPAKW 100
    TYDNIDYMKG QMQSMGLAID WSREIATCKP DYYKWNQWLF LKMLEKGIAY 150
    KKTGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYLRITQYAD 200
    ELLNDLDGLG WPERVKIMQQ NWIGKSFGVN FGFPYELDGE KALLRVFTTR 250
    ADTIMGVTFC AVAAEHPLAT RLAQGKPELQ AFIDECKRGG VAEADVATME 300
    KKGVATGFSV SHPLTGEPVE VWIGNYVLMS YGEGAVMGVP GHDERDFAFA 350
    KKYGLPIKQV IASEGQTYSL DAWQEWYGDK ETAVCVNSGK YDGLRYADAV 400
    DAVAADLKAG GYGDKQVTWR LRDWGVSRQR YWGTPIPIIH CPSCGDVPVP 450
    EQDLPVVLPE DLVPDGSGNP LAKSEAFLNC SCPKCGAAAK RETDTMDTFV 500
    DSSWYFSRYT APDADTMVDA RTDYWMPMDQ YIGGIEHAIL HLLYSRFWTK 550
    VMRDLGLVKF GEPAKNLLTQ GMVLNETFYR EDASGKKTWY NPADVTVTHD 600
    DKGRPVGATL NTDGQPVVLG GIEKMSKSKN NGVDPQVLID QYGADTARLF 650
    TMFAAPPEQQ LEWSGAGVEG ASRFLRRVWS FGATNREALA ARAGFDAAAL 700
    GDADKALRRE IYSVLKQADF DYQRLQYNTV VSAAMKMLNA IDGAKGATPA 750
    VLRETYGVLL RVLYPVVPHV TFELWKALGY ADEFGPLLDA PWPKVDEAAL 800
    EQAEIELVLQ VNGKVRGALK VAKGASRDAI EAAAVADEAF AKFSDGKPAK 850
    KIVVVPGRLV NIVV 864
    Length:864
    Mass (Da):95,838
    Last modified:May 20, 2008 - v1
    Checksum:iD733CE59C376B0B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB63072.1.
    RefSeqiYP_001807288.1. NC_010551.1.

    Genome annotation databases

    EnsemblBacteriaiACB63072; ACB63072; BamMC406_0575.
    GeneIDi6178070.
    KEGGibac:BamMC406_0575.
    PATRICi19030460. VBIBurAmb82852_0579.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB63072.1 .
    RefSeqi YP_001807288.1. NC_010551.1.

    3D structure databases

    ProteinModelPortali B1YTA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398577.BamMC406_0575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB63072 ; ACB63072 ; BamMC406_0575 .
    GeneIDi 6178070.
    KEGGi bac:BamMC406_0575.
    PATRICi 19030460. VBIBurAmb82852_0579.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BAMB398577:GH38-596-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
      , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC40-6.

    Entry informationi

    Entry nameiSYL_BURA4
    AccessioniPrimary (citable) accession number: B1YTA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3