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Reviewed, UniProtKB/Swiss-Prot B1YT76 (HUTI_BURA4)

Last modified November 3, 2009. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase
Gene names
Name: hutI
Ordered Locus Names: BamMC406_2084
OrganismBurkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]
Taxonomic identifier398577 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372

Cofactor

Binds 1 zinc or iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the hutI family.

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Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionimidazolonepropionase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Imidazolonepropionase HAMAP MF_00372
PRO_1000121535

Sites

Metal binding681Zinc or iron By similarity
Metal binding701Zinc or iron By similarity
Metal binding2381Zinc or iron By similarity
Metal binding3131Zinc or iron By similarity
Binding site771Substrate By similarity
Binding site901Substrate By similarity
Binding site1401Substrate By similarity
Binding site1731Substrate By similarity
Binding site2411Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
B1YT76-1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: DF39A0EDD6FF4086

FASTA40744,098
        10         20         30         40         50         60 
MKPTVWHHLR LCPHGHPDET IDDAAIAVDE TGTIVWLGAF SALPHGYAHW QREDLHGAWV 

        70         80         90        100        110        120 
TPGLVDCHTH LVYGGTRADE FAQRLAGVSY EEIARQGGGI VSTVRATRAA DETTLFVQAA 

       130        140        150        160        170        180 
ARLQPLLAEG VSAIEIKSGY GLDLASERKM LRVARQLGER FPVSVYTTFL GAHALPPEYA 

       190        200        210        220        230        240 
GRADAYIDEV CERMLPTLAD EGLVDAVDVF CERIGFSLAQ TERVFEAATR RGLPVKLHAE 

       250        260        270        280        290        300 
QLSNAGGTAL AARYRALSAD HLEFLDEAGV EAMKAAGTVA VLLPGAYYFI RETQLPPIEL 

       310        320        330        340        350        360 
LRKHGVPIAL ATDHNPGTSP LESLLLTLNM GCTLFRMTVP EVLQGVTRHA AAALGRADRH 

       370        380        390        400 
GALEIGRQAD FAVWSVGSLA ELAYWIGRPL CEQVVRGGAT VFRRMNG

« Hide

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References

[1]"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001025 Genomic DNA. Translation: ACB64565.1.
RefSeqYP_001808781.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6177033.
KEGGbac:BamMC406_2084.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMNMACTL.

Family and domain databases

HAMAPMF_00372.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR005920. HutI.
[Graphical view]
PfamPF01979. Amidohydro_1. 2 hits.
[Graphical view]
TIGRFAMsTIGR01224. hutI. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHUTI_BURA4
AccessionPrimary (citable) accession number: B1YT76
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents