B1YSF5 (TRPC_BURA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BamMC406_0460

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095853

Sequences

	Sequence		Length	Mass (Da)
	B1YSF5 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 819C828918146826	FASTA	261	28,555
	10 20 30 40 50 60 MSDILDRIIA VKREEVAAAM RSAPLEALKL EASARDLRDF VGALRAKQAA GHAAVIAEVK 70 80 90 100 110 120 KASPSKGVLR EHFVPADIAR SYAAHGAACL SVLTDEQFFQ GSVRYLEEAR AACTLPVLRK 130 140 150 160 170 180 DFIVDAYQIL EARAMGADAI LLIAAALDTP LMQDLEAYAH SLGLAVLVEV HDRDEMEQAL 190 200 210 220 230 240 TLKTPLLGIN NRNLRTFETS IQTTLDMLDM IPPERMVVTE SGILSRTDVD TMRAANVNAF 250 260 LVGEAFMRAD QPGEELARMF F

References

[1]

"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC40-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001025 Genomic DNA. Translation: ACB62957.1.
RefSeq	YP_001807173.1. NC_010551.1.
3D structure databases
ProteinModelPortal	B1YSF5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YSF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6177646.
GenomeReviews	Gene locus BamMC406_0460 in contig CP001025_GR.
KEGG	bac:BamMC406_0460.
PATRIC	19030194. VBIBurAmb82852_0453.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BAMB398577:BAMMC406_0460-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BURA4

Accession

Primary (citable) accession number: B1YSF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program