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Reviewed, UniProtKB/Swiss-Prot B1YS68 (DXR_BURA4)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name: dxr
Ordered Locus Names: BamMC406_1915
OrganismBurkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]
Taxonomic identifier398577 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3983981-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_1000098475

Regions

Nucleotide binding8 – 3730NADP By similarity

Sites

Metal binding1511Divalent metal cation By similarity
Metal binding1531Divalent metal cation By similarity
Metal binding2241Divalent metal cation By similarity
Binding site1261Substrate By similarity
Binding site1531Substrate By similarity
Binding site1791Substrate By similarity
Binding site2021Substrate By similarity
Binding site2241Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
B1YS68-1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 94FE636B82D97541

FASTA39842,197
        10         20         30         40         50         60 
MQKRLTLLGS TGSIGDSTLD VVARHPERFS VYALTAHRNG DKLVEQCLRF APEVAVVGDA 

        70         80         90        100        110        120 
NTAAHVEAKL RAAGSKTIVL YGPQALVDVS KSDGCDTVVA AIVGAAGLAP SLAAARAGKR 

       130        140        150        160        170        180 
ILLANKESLV MSGAIFMDAV RDHGAILLPV DSEHNAIFQC MPRDENEHGG ISKIILTASG 

       190        200        210        220        230        240 
GPFRTREPAT LADVTPDEAC KHPNWVMGRK ISVDSATMMN KGLEVIEAHW IFGLPGDRID 

       250        260        270        280        290        300 
VLIHPQSVIH SLVSYRDGSV LAQLGNPDMR TPIAHALAFP ERVDAGVDQL DLAQIAQLSF 

       310        320        330        340        350        360 
EKPDYTRFPC LALALKALEE GGIASAALNA ANEIAVEAFL ERRIGFMAIA ATVDAVLNAL 

       370        380        390 
PNRSPNGLDD VLAADAEARR LAAEIIAKAP APRVERTV

« Hide

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References

[1]"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. expand/collapse author list , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001025 Genomic DNA. Translation: ACB64397.1.
RefSeqYP_001808613.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6176487.
KEGGbac:BamMC406_1915.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIHSMVEY.

Family and domain databases

HAMAPMF_00183.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
[Graphical view]
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameDXR_BURA4
AccessionPrimary (citable) accession number: B1YS68
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents