B1YQQ3 (GCST_BURA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BamMC406_0145

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Aminomethyltransferase HAMAP MF_00259		PRO_1000114080

Sequences

	Sequence		Length	Mass (Da)
	B1YQQ3 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: C571771873C150D6	FASTA	372	40,210
	10 20 30 40 50 60 MTALNHTPLN AAHRALNARM VDFGGWDMPV NYGSQIEEHE AVRTDAGMFD VSHMCVVDFT 70 80 90 100 110 120 GSRVRAFFEH AIANNVGKLK TPGKALYSCL LNPQGGVIDD LIVYYFTEDF FRVVVNAGTA 130 140 150 160 170 180 EKDIAWFNQL NEQGGYGLTI APRRDFAIVA VQGPNAREKV WTTVPAARAA TSELKPFNAA 190 200 210 220 230 240 RVAGTPFGEL TVARTGYTGE DGFEVIVPAV HVEALWTALQ QNGVRPCGLG ARDTLRLEAG 250 260 270 280 290 300 MNLYGQDMDE TVSPLDAGLA WTVDLSAPRD FVGRDALERD GTRAAFVGLI LQKENGKAGG 310 320 330 340 350 360 VLRAHQKVVT PHGEGEITSG TFSPSMQESI AFARVPAAVH VGDTIHVQIR DKQLPARVVK 370 LPFVRNGKVL AA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC40-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001025 Genomic DNA. Translation: ACB62647.1.
RefSeq	YP_001806863.1. NC_010551.1.
3D structure databases
ProteinModelPortal	B1YQQ3.
SMR	B1YQQ3. Positions 6-371.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YQQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6179059.
GenomeReviews	Gene locus BamMC406_0145 in contig CP001025_GR.
KEGG	bac:BamMC406_0145.
PATRIC	19029545. VBIBurAmb82852_0141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	BAMB398577:BAMMC406_0145-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BURA4

Accession

Primary (citable) accession number: B1YQQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program