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B1YQQ1

- GCSP_BURA4

UniProt

B1YQQ1 - GCSP_BURA4

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAMB398577:GH38-147-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BamMC406_0143
    OrganismiBurkholderia ambifaria (strain MC40-6)
    Taxonomic identifieri398577 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000001680: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 975975Glycine dehydrogenase (decarboxylating)PRO_1000190207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei723 – 7231N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi398577.BamMC406_0143.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YQQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1YQQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFASR    50
    AALIDAVIPA SIRRAETLPL GPFAQPKSEA EALAALRALA DKNQVFRSYI 100
    GQGYHDTHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVA 150
    DLTGLAISNA SLLDEATAAA EAMTLLQRTG KPASNVFYVA DDVLPQTLEV 200
    IRTRALPIGI EVKTGPAADA AQANAFGVLL QYPGVNGDVR DYRALTEAIH 250
    AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPM GFGGPHAAYL 300
    AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA 350
    QALLAIMASM YAVYHGPHGL KTIALRVNRI AALFAAGVKQ LGFATVNDTF 400
    FDTLTIDTGA RTAQVHEFAK ARRINLRRVS ATQVGVSFDE TTTRDDLAAL 450
    LAVFAQAAGG TAPSVDALDA GAAGVAALPA GLERTSAYLT HHVFNRHHSE 500
    TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGRIHP 550
    FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA 600
    YHASRGEAHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL 650
    KAKAEQHAND LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM 700
    NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPVA VGAHLAKFLP 750
    NQRSTGYTRE EDGIGAVSAA PYGSASILPI SWMYIAMMGA KNLTAATETA 800
    ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKET SGISVDDVAK 850
    RLMDYGFHAP TMSFPVPGTL MVEPTESESQ EELDRFIAAM IAIREEIRAV 900
    EEGRADREDN PLRHAPHTAA VVTANEWPHA YSREQAAYPV ASLGTNKYWP 950
    PVGRADNAYG DRNLFCSCVP MSDYA 975
    Length:975
    Mass (Da):104,289
    Last modified:May 20, 2008 - v1
    Checksum:i93D43F60C3AB868C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB62645.1.
    RefSeqiYP_001806861.1. NC_010551.1.

    Genome annotation databases

    EnsemblBacteriaiACB62645; ACB62645; BamMC406_0143.
    GeneIDi6177444.
    KEGGibac:BamMC406_0143.
    PATRICi19029541. VBIBurAmb82852_0139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB62645.1 .
    RefSeqi YP_001806861.1. NC_010551.1.

    3D structure databases

    ProteinModelPortali B1YQQ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398577.BamMC406_0143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB62645 ; ACB62645 ; BamMC406_0143 .
    GeneIDi 6177444.
    KEGGi bac:BamMC406_0143.
    PATRICi 19029541. VBIBurAmb82852_0139.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BAMB398577:GH38-147-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
      , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC40-6.

    Entry informationi

    Entry nameiGCSP_BURA4
    AccessioniPrimary (citable) accession number: B1YQQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3