B1YNW1 (IOLG_BURA4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	BamMC406_1347

Organism

Burkholderia ambifaria (strain MC40-6) [Complete proteome] [HAMAP]

Taxonomic identifier

398577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352559

Sequences

	Sequence		Length	Mass (Da)
	B1YNW1 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 4B823BB514C83CF9	FASTA	337	36,527
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHIRR LTRKLSGARV VAVNDIDPQQ ARDAVTKYGL DAEIYGDGHE 70 80 90 100 110 120 VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA VTAQGCMRIV EAEVAHGRRL 130 140 150 160 170 180 VQVGFMRPYD EGYRALKHVI DSGGIGAPLM LHCAHRNQSV GERYTTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLGEDYT SAQVVYPKKT RHASAHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGENGIAKL PDPPAVGLKH AARQSVEIMT DWKERFIASY DVELQAFIDG VRQGALTGPS 310 320 330 AWDGYAAAVA ADACVRAQQS GAVEPIAMAE RPAFYRG

References

[1]

"Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A. , Ramette A., Konstantinidis K., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC40-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001025 Genomic DNA. Translation: ACB63835.1.
RefSeq	YP_001808051.1. NC_010551.1.
3D structure databases
ProteinModelPortal	B1YNW1.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YNW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6176271.
GenomeReviews	Gene locus BamMC406_1347 in contig CP001025_GR.
KEGG	bac:BamMC406_1347.
PATRIC	19032094. VBIBurAmb82852_1378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK896889.
Enzyme and pathway databases
BioCyc	BAMB398577:BAMMC406_1347-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BURA4

Accession

Primary (citable) accession number: B1YNW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program