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B1YMV8

- B1YMV8_BURA4

UniProt

B1YMV8 - B1YMV8_BURA4

Protein
Submitted name:

Carbamoyl-phosphate synthase, large subunit

Gene

BamMC406_1181

Organism
Burkholderia ambifaria (strain MC40-6)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.SAAS annotation

    Cofactori

    Binds 4 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. arginine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisSAAS annotation, Pyrimidine biosynthesisSAAS annotation

    Keywords - Ligandi

    MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation

    Enzyme and pathway databases

    BioCyciBAMB398577:GH38-1218-MONOMER.
    UniPathwayiUPA00068; UER00171.
    UPA00070; UER00115.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Carbamoyl-phosphate synthase, large subunitImported
    Gene namesi
    Ordered Locus Names:BamMC406_1181Imported
    OrganismiBurkholderia ambifaria (strain MC40-6)Imported
    Taxonomic identifieri398577 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000001680: Chromosome 1

    Interactioni

    Subunit structurei

    Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.SAAS annotation

    Protein-protein interaction databases

    STRINGi398577.BamMC406_1181.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YMV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0458.
    HOGENOMiHOG000234582.
    KOiK01955.
    OMAiGSDRIWY.
    OrthoDBiEOG6J1DC6.

    Family and domain databases

    Gene3Di1.10.1030.10. 1 hit.
    3.30.1490.20. 2 hits.
    3.30.470.20. 2 hits.
    3.40.50.1380. 1 hit.
    3.40.50.20. 2 hits.
    HAMAPiMF_01210_A. CPSase_L_chain_A.
    MF_01210_B. CPSase_L_chain_B.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006275. CarbamoylP_synth_lsu.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005480. CarbamoylP_synth_lsu_oligo.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR005483. CbamoylP_synth_lsu_CPSase_dom.
    IPR011607. MGS-like_dom.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF00289. CPSase_L_chain. 2 hits.
    PF02786. CPSase_L_D2. 2 hits.
    PF02787. CPSase_L_D3. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PRINTSiPR00098. CPSASE.
    SMARTiSM01096. CPSase_L_D3. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48108. SSF48108. 1 hit.
    SSF52335. SSF52335. 1 hit.
    SSF52440. SSF52440. 2 hits.
    TIGRFAMsiTIGR01369. CPSaseII_lrg. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 2 hits.
    PS00866. CPSASE_1. 2 hits.
    PS00867. CPSASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1YMV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKRTDIKSI LIIGAGPIII GQACEFDYSG AQACKALREE GYKVVLVNSN     50
    PATIMTDPNT ADVTYIEPIT WEVVARIIEK ERPDAILPTM GGQTALNCAL 100
    DLHHHGVLEK FGVELIGASP EAIDKAEDRQ KFKDAMTKIG LGSAKSGIAH 150
    SMEEATQVHA EIMAYTGGSG YPVVIRPSFT LGGSGGGIAY NREEFEEICK 200
    RGLDLSPTRE LLIEESLLGW KEYEMEVVRD RADNCIIVCS IENLDPMGVH 250
    TGDSITVAPA QTLTDKEYQI LRNASLAVLR EIGVDTGGSN VQFSINPKDG 300
    RMVVIEMNPR VSRSSALASK ATGFPIAKVA AKLAVGYTLD ELKNEITGGQ 350
    TPASFEPTID YVVTKIPRFA FEKFREADSR LTTQMKSVGE VMAIGRTFQE 400
    SFQKALRGLE VGVDGLDEKS TDRDEIAIEI HEPGPDRIWY VGDAFRIGMT 450
    AEEIFAETAI DPWFLAQIEQ IILKEKALSG RTLASLTFDE LRFLKQSGFS 500
    DRRLAKLLGA TPEDVRKRRV ELNVRPVYKR VDTCAAEFAT KTAYMYSTYE 550
    EECEAQPTTN KKIMVLGGGP NRIGQGIEFD YCCVHAALAM REDGYETIMV 600
    NCNPETVSTD YDTSDRLYFE PLTLEDVLEI VDKEKPVGVI VQYGGQTPLK 650
    LALDLEAHGV PIVGTSPDMI DAAEDRERFQ KLLQDLGLRQ PPNRTARAEE 700
    EALALAAEIG YPLVVRPSYV LGGRAMEIVH EPRDLERYMR EAVKVSNDSP 750
    VLLDRFLNDA IECDVDCICD GEAVFIGGVM EHIEQAGVHS GDSACSLPPY 800
    SLSKETVAEL KRQTGAMAKA LNVVGLMNVQ FAIQQVPQAD GSKQDIIYVL 850
    EVNPRASRTV PYVSKATSLP LAKIAARAMV GQKLAQQGVT KEVEPPYFSV 900
    KEAVFPFVKF PTVDPVLGPE MRSTGEVMGV GQTFGEALFK SQLAAGSRLP 950
    ESGTVLLTVM DADKPKAVEV ARMLHDLGYP IVATKGTAAA IEAAGVPVKV 1000
    VNKVKDGRPH IVDMIKNGEI ALVFTTVDET RQAIADSRSI RMSAQAHKVT 1050
    YYTTMSGARA AVEGLRYLKD LEVYDLQGLH ARLN 1084
    Length:1,084
    Mass (Da):118,534
    Last modified:May 20, 2008 - v1
    Checksum:i03C125233E06ED28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB63672.1.
    RefSeqiYP_001807888.1. NC_010551.1.

    Genome annotation databases

    EnsemblBacteriaiACB63672; ACB63672; BamMC406_1181.
    GeneIDi6178800.
    KEGGibac:BamMC406_1181.
    PATRICi19031760. VBIBurAmb82852_1213.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001025 Genomic DNA. Translation: ACB63672.1 .
    RefSeqi YP_001807888.1. NC_010551.1.

    3D structure databases

    ProteinModelPortali B1YMV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398577.BamMC406_1181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB63672 ; ACB63672 ; BamMC406_1181 .
    GeneIDi 6178800.
    KEGGi bac:BamMC406_1181.
    PATRICi 19031760. VBIBurAmb82852_1213.

    Phylogenomic databases

    eggNOGi COG0458.
    HOGENOMi HOG000234582.
    KOi K01955.
    OMAi GSDRIWY.
    OrthoDBi EOG6J1DC6.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00171 .
    UPA00070 ; UER00115 .
    BioCyci BAMB398577:GH38-1218-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1030.10. 1 hit.
    3.30.1490.20. 2 hits.
    3.30.470.20. 2 hits.
    3.40.50.1380. 1 hit.
    3.40.50.20. 2 hits.
    HAMAPi MF_01210_A. CPSase_L_chain_A.
    MF_01210_B. CPSase_L_chain_B.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006275. CarbamoylP_synth_lsu.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005480. CarbamoylP_synth_lsu_oligo.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR005483. CbamoylP_synth_lsu_CPSase_dom.
    IPR011607. MGS-like_dom.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF00289. CPSase_L_chain. 2 hits.
    PF02786. CPSase_L_D2. 2 hits.
    PF02787. CPSase_L_D3. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00098. CPSASE.
    SMARTi SM01096. CPSase_L_D3. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48108. SSF48108. 1 hit.
    SSF52335. SSF52335. 1 hit.
    SSF52440. SSF52440. 2 hits.
    TIGRFAMsi TIGR01369. CPSaseII_lrg. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 2 hits.
    PS00866. CPSASE_1. 2 hits.
    PS00867. CPSASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
      , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC40-6Imported.

    Entry informationi

    Entry nameiB1YMV8_BURA4
    AccessioniPrimary (citable) accession number: B1YMV8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3