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B1YMV8

- B1YMV8_BURA4

UniProt

B1YMV8 - B1YMV8_BURA4

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Protein
Submitted name: Carbamoyl-phosphate synthase, large subunit
Gene
BamMC406_1181
Organism
Burkholderia ambifaria (strain MC40-6)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.SAAS annotations

Cofactori

Binds 4 magnesium or manganese ions per subunit By similarity.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisSAAS annotations, Pyrimidine biosynthesisSAAS annotations

Keywords - Ligandi

MagnesiumSAAS annotations, ManganeseSAAS annotations, Metal-bindingSAAS annotations

Enzyme and pathway databases

BioCyciBAMB398577:GH38-1218-MONOMER.
UniPathwayiUPA00068; UER00171.
UPA00070; UER00115.

Names & Taxonomyi

Protein namesi
Submitted name:
Carbamoyl-phosphate synthase, large subunitImported
Gene namesi
Ordered Locus Names:BamMC406_1181Imported
OrganismiBurkholderia ambifaria (strain MC40-6)Imported
Taxonomic identifieri398577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001680: Chromosome 1

Interactioni

Subunit structurei

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.SAAS annotations

Protein-protein interaction databases

STRINGi398577.BamMC406_1181.

Structurei

3D structure databases

ProteinModelPortaliB1YMV8.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0458.
HOGENOMiHOG000234582.
KOiK01955.
OMAiGSDRIWY.
OrthoDBiEOG6J1DC6.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
HAMAPiMF_01210_A. CPSase_L_chain_A.
MF_01210_B. CPSase_L_chain_B.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PRINTSiPR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
TIGRFAMsiTIGR01369. CPSaseII_lrg. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YMV8-1 [UniParc]FASTAAdd to Basket

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MPKRTDIKSI LIIGAGPIII GQACEFDYSG AQACKALREE GYKVVLVNSN     50
PATIMTDPNT ADVTYIEPIT WEVVARIIEK ERPDAILPTM GGQTALNCAL 100
DLHHHGVLEK FGVELIGASP EAIDKAEDRQ KFKDAMTKIG LGSAKSGIAH 150
SMEEATQVHA EIMAYTGGSG YPVVIRPSFT LGGSGGGIAY NREEFEEICK 200
RGLDLSPTRE LLIEESLLGW KEYEMEVVRD RADNCIIVCS IENLDPMGVH 250
TGDSITVAPA QTLTDKEYQI LRNASLAVLR EIGVDTGGSN VQFSINPKDG 300
RMVVIEMNPR VSRSSALASK ATGFPIAKVA AKLAVGYTLD ELKNEITGGQ 350
TPASFEPTID YVVTKIPRFA FEKFREADSR LTTQMKSVGE VMAIGRTFQE 400
SFQKALRGLE VGVDGLDEKS TDRDEIAIEI HEPGPDRIWY VGDAFRIGMT 450
AEEIFAETAI DPWFLAQIEQ IILKEKALSG RTLASLTFDE LRFLKQSGFS 500
DRRLAKLLGA TPEDVRKRRV ELNVRPVYKR VDTCAAEFAT KTAYMYSTYE 550
EECEAQPTTN KKIMVLGGGP NRIGQGIEFD YCCVHAALAM REDGYETIMV 600
NCNPETVSTD YDTSDRLYFE PLTLEDVLEI VDKEKPVGVI VQYGGQTPLK 650
LALDLEAHGV PIVGTSPDMI DAAEDRERFQ KLLQDLGLRQ PPNRTARAEE 700
EALALAAEIG YPLVVRPSYV LGGRAMEIVH EPRDLERYMR EAVKVSNDSP 750
VLLDRFLNDA IECDVDCICD GEAVFIGGVM EHIEQAGVHS GDSACSLPPY 800
SLSKETVAEL KRQTGAMAKA LNVVGLMNVQ FAIQQVPQAD GSKQDIIYVL 850
EVNPRASRTV PYVSKATSLP LAKIAARAMV GQKLAQQGVT KEVEPPYFSV 900
KEAVFPFVKF PTVDPVLGPE MRSTGEVMGV GQTFGEALFK SQLAAGSRLP 950
ESGTVLLTVM DADKPKAVEV ARMLHDLGYP IVATKGTAAA IEAAGVPVKV 1000
VNKVKDGRPH IVDMIKNGEI ALVFTTVDET RQAIADSRSI RMSAQAHKVT 1050
YYTTMSGARA AVEGLRYLKD LEVYDLQGLH ARLN 1084
Length:1,084
Mass (Da):118,534
Last modified:May 20, 2008 - v1
Checksum:i03C125233E06ED28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001025 Genomic DNA. Translation: ACB63672.1.
RefSeqiYP_001807888.1. NC_010551.1.

Genome annotation databases

EnsemblBacteriaiACB63672; ACB63672; BamMC406_1181.
GeneIDi6178800.
KEGGibac:BamMC406_1181.
PATRICi19031760. VBIBurAmb82852_1213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001025 Genomic DNA. Translation: ACB63672.1 .
RefSeqi YP_001807888.1. NC_010551.1.

3D structure databases

ProteinModelPortali B1YMV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398577.BamMC406_1181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB63672 ; ACB63672 ; BamMC406_1181 .
GeneIDi 6178800.
KEGGi bac:BamMC406_1181.
PATRICi 19031760. VBIBurAmb82852_1213.

Phylogenomic databases

eggNOGi COG0458.
HOGENOMi HOG000234582.
KOi K01955.
OMAi GSDRIWY.
OrthoDBi EOG6J1DC6.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00171 .
UPA00070 ; UER00115 .
BioCyci BAMB398577:GH38-1218-MONOMER.

Family and domain databases

Gene3Di 1.10.1030.10. 1 hit.
3.30.1490.20. 2 hits.
3.30.470.20. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
HAMAPi MF_01210_A. CPSase_L_chain_A.
MF_01210_B. CPSase_L_chain_B.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PRINTSi PR00098. CPSASE.
SMARTi SM01096. CPSase_L_D3. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48108. SSF48108. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
TIGRFAMsi TIGR01369. CPSaseII_lrg. 1 hit.
PROSITEi PS50975. ATP_GRASP. 2 hits.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6."
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.
    , Ramette A., Konstantinidis K., Tiedje J., Richardson P.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC40-6.

Entry informationi

Entry nameiB1YMV8_BURA4
AccessioniPrimary (citable) accession number: B1YMV8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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