B1YMP6 (FABZ_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl ACP dehydrase
EC=4.2.1.-

Gene names

Name:	fabZ
Ordered Locus Names:	Exig_2658

Organism

Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]

Taxonomic identifier

262543 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in saturated fatty acids biosynthesis By similarity. HAMAP MF_00406
Subcellular location	Cytoplasm By similarity HAMAP MF_00406.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydro-lyase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase HAMAP MF_00406		PRO_1000123639
Sites
	Active site	48	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1YMP6 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 0575C757BD5F8DCB	FASTA	140	15,593
	10 20 30 40 50 60 MYTIEQIKEV IPHRYPFLLV DRILEVEEGK RAVGIKNVTA NEEFFNGHFP DYNVMPGVLI 70 80 90 100 110 120 VEALAQVGAF AVLKMEQNQG KLAFFAGIEN CRFKRQVVPG DQLRLEVELT KLRGPIGKGR 130 140 ATATVDGEVA CTAELTFAIK

References

[1]

"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001022 Genomic DNA. Translation: ACB62106.1.
RefSeq	YP_001815123.1. NC_010556.1.
3D structure databases
ProteinModelPortal	B1YMP6.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YMP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6172828.
GenomeReviews	Gene locus Exig_2658 in contig CP001022_GR.
KEGG	esi:Exig_2658.
PATRIC	32138962. VBIExiSib53410_2702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG433282.
OMA	KKQVTPG.
ProtClustDB	PRK00006.
Family and domain databases
HAMAP	MF_00406. FabZ. [Tree]
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
KO	K02372.
Pfam	PF07977. FabA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01750. FabZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABZ_EXIS2

Accession

Primary (citable) accession number: B1YMP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program