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Protein

DNA topoisomerase

Gene

Exig_0961

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciESIB262543:GHBP-1031-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Ordered Locus Names:Exig_0961Imported
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)Imported
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_0961.

Structurei

3D structure databases

ProteinModelPortaliB1YLV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 130ToprimInterPro annotationAdd BLAST130
Domaini130 – 225TOP1BcInterPro annotationAdd BLAST96
Domaini269 – 543TOP1AcInterPro annotationAdd BLAST275

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.
OrthoDBiPOG091H028X.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YLV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLIIAEKPK QAEKLAAPYP SVKRDGYIEI KPCDRFPAGA KLAYAVGHLC
60 70 80 90 100
ELQEPAHYDA KWKRWNYDHL PIIPERFDYR LSRGKSKTFQ VIKKLLNERT
110 120 130 140 150
TTSIIIASDA EREGEAIVRL ILRLANNAKP IQRLWISSLT PQAVDHGFAN
160 170 180 190 200
LLDGKETENL FHEAMSRACA DWLIGMNASR AYTTLLKKKG IADVFSLGRV
210 220 230 240 250
QTPTLSLIVE REKQIENFRP ETFFEVEADF TRYTGKYINP KKQTKITERS
260 270 280 290 300
LAEAIVARTT GTGTVAAVEK TEQVEKPPFW FSLSLLQTEA SRRFGLGAKE
310 320 330 340 350
TLDIAQKLYI RGWISYPRTD SSFVSKDEAS QFPAILNRLL KQPEYTELTD
360 370 380 390 400
LVTNNLMNNK RYVNSAKVSD HYAIIPTEEA GAVAKLSGRD AQVYDLIVRR
410 420 430 440 450
FLAAFAADAR SEKTEIITER EQDRFLTKGS RSLELGFKKV LKIEAKEQEL
460 470 480 490 500
PAVEVGQPVP IKGAKLLEKQ TEPPKRYTEG TLILGMKTAG KVLENELQAI
510 520 530 540 550
MKEIEGLGTE ATRAGIIDGL KRREYIQVKK KELHPTAKGR ILIEAVSGSI
560 570 580 590 600
LASPEMTAKW ESRLDQIGKG EASAAQFVDQ AKKLSQHLVQ DAKTRVEQLE
610 620 630 640 650
VDPTQVPAKR ARGATNRPVG ICPVCQAELL DRGKFYGCSA YQKNNCGFTL
660 670 680 690 700
PKTILGARLT QTELKKMLAN GKTKPLEMKK NGRTFQAMLY LEQHQLKFEF

VKGEA
Length:705
Mass (Da):79,245
Last modified:May 20, 2008 - v1
Checksum:i7282F1D0FC712447
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB60441.1.
RefSeqiWP_012369865.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB60441; ACB60441; Exig_0961.
KEGGiesi:Exig_0961.
PATRICi32135505. VBIExiSib53410_0978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB60441.1.
RefSeqiWP_012369865.1. NC_010556.1.

3D structure databases

ProteinModelPortaliB1YLV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262543.Exig_0961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB60441; ACB60441; Exig_0961.
KEGGiesi:Exig_0961.
PATRICi32135505. VBIExiSib53410_0978.

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.
OrthoDBiPOG091H028X.

Enzyme and pathway databases

BioCyciESIB262543:GHBP-1031-MONOMER.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB1YLV8_EXIS2
AccessioniPrimary (citable) accession number: B1YLV8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.