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B1YLN8

- GCSPB_EXIS2

UniProt

B1YLN8 - GCSPB_EXIS2

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciESIB262543:GHBP-967-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Exig_0891
    OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
    Taxonomic identifieri262543 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000001681: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi262543.Exig_0891.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YLN8.
    SMRiB1YLN8. Positions 8-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1YLN8-1 [UniParc]FASTAAdd to Basket

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    MHKTSEQTLI FEISKAGRVA YSLPLPTVDE VAAEELLPAH LLRQEDVELP    50
    EVSELDLVRH YTALSNRNHG VDSGFYPLGS CTMKYNPKIN EDMARLPGFA 100
    HIHPLQPVES VQGALGLMYD LQEKLAVITG MDEVTLQPAA GAHGEWTGLM 150
    LIKAYHHARG DFKRTKVLVP DSAHGTNPAS ASVAGFDTVT VLSDERGLVD 200
    LADLKSKVGE DTAALMLTNP NTLGLFESDI VEIAKAVHEA GGKLYYDGAN 250
    SNAIMGIARP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPV GVKKDLIPYL 300
    PKPIVAKTAE GFVLDYDRPE SIGRVKPFYG NFGINVRAYS YIRTMGGAGL 350
    ARVSKEAVLN ANYMLARLKG AYDAPYDVYC KHEFVLSGRR QKALGVRTLD 400
    IAKRLLDFGY HPPTIYFPLN VEECIMIEPT ETESKETLDD FCDAMLQIAK 450
    EVEETPDVVL NAPHTTVVKR MDETLAARKP ILRYQPKQEV HV 492
    Length:492
    Mass (Da):53,845
    Last modified:May 20, 2008 - v1
    Checksum:i96ECCA89C1577794
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001022 Genomic DNA. Translation: ACB60371.1.
    RefSeqiYP_001813388.1. NC_010556.1.

    Genome annotation databases

    EnsemblBacteriaiACB60371; ACB60371; Exig_0891.
    GeneIDi6172913.
    KEGGiesi:Exig_0891.
    PATRICi32135363. VBIExiSib53410_0907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001022 Genomic DNA. Translation: ACB60371.1 .
    RefSeqi YP_001813388.1. NC_010556.1.

    3D structure databases

    ProteinModelPortali B1YLN8.
    SMRi B1YLN8. Positions 8-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262543.Exig_0891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB60371 ; ACB60371 ; Exig_0891 .
    GeneIDi 6172913.
    KEGGi esi:Exig_0891.
    PATRICi 32135363. VBIExiSib53410_0907.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci ESIB262543:GHBP-967-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17290 / JCM 13490 / 255-15.

    Entry informationi

    Entry nameiGCSPB_EXIS2
    AccessioniPrimary (citable) accession number: B1YLN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3