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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciESIB262543:GHBP-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Exig_0891
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi262543.Exig_0891.

Structurei

3D structure databases

ProteinModelPortaliB1YLN8.
SMRiB1YLN8. Positions 8-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V_dom.
IPR023012. GcvPB.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YLN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKTSEQTLI FEISKAGRVA YSLPLPTVDE VAAEELLPAH LLRQEDVELP
60 70 80 90 100
EVSELDLVRH YTALSNRNHG VDSGFYPLGS CTMKYNPKIN EDMARLPGFA
110 120 130 140 150
HIHPLQPVES VQGALGLMYD LQEKLAVITG MDEVTLQPAA GAHGEWTGLM
160 170 180 190 200
LIKAYHHARG DFKRTKVLVP DSAHGTNPAS ASVAGFDTVT VLSDERGLVD
210 220 230 240 250
LADLKSKVGE DTAALMLTNP NTLGLFESDI VEIAKAVHEA GGKLYYDGAN
260 270 280 290 300
SNAIMGIARP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPV GVKKDLIPYL
310 320 330 340 350
PKPIVAKTAE GFVLDYDRPE SIGRVKPFYG NFGINVRAYS YIRTMGGAGL
360 370 380 390 400
ARVSKEAVLN ANYMLARLKG AYDAPYDVYC KHEFVLSGRR QKALGVRTLD
410 420 430 440 450
IAKRLLDFGY HPPTIYFPLN VEECIMIEPT ETESKETLDD FCDAMLQIAK
460 470 480 490
EVEETPDVVL NAPHTTVVKR MDETLAARKP ILRYQPKQEV HV
Length:492
Mass (Da):53,845
Last modified:May 20, 2008 - v1
Checksum:i96ECCA89C1577794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB60371.1.
RefSeqiWP_012369795.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB60371; ACB60371; Exig_0891.
KEGGiesi:Exig_0891.
PATRICi32135363. VBIExiSib53410_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB60371.1.
RefSeqiWP_012369795.1. NC_010556.1.

3D structure databases

ProteinModelPortaliB1YLN8.
SMRiB1YLN8. Positions 8-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262543.Exig_0891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB60371; ACB60371; Exig_0891.
KEGGiesi:Exig_0891.
PATRICi32135363. VBIExiSib53410_0907.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciESIB262543:GHBP-967-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V_dom.
IPR023012. GcvPB.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiGCSPB_EXIS2
AccessioniPrimary (citable) accession number: B1YLN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.