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B1YLN8

- GCSPB_EXIS2

UniProt

B1YLN8 - GCSPB_EXIS2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, Exig_0891
Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciESIB262543:GHBP-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Exig_0891
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000132500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi262543.Exig_0891.

Structurei

3D structure databases

ProteinModelPortaliB1YLN8.
SMRiB1YLN8. Positions 8-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YLN8-1 [UniParc]FASTAAdd to Basket

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MHKTSEQTLI FEISKAGRVA YSLPLPTVDE VAAEELLPAH LLRQEDVELP    50
EVSELDLVRH YTALSNRNHG VDSGFYPLGS CTMKYNPKIN EDMARLPGFA 100
HIHPLQPVES VQGALGLMYD LQEKLAVITG MDEVTLQPAA GAHGEWTGLM 150
LIKAYHHARG DFKRTKVLVP DSAHGTNPAS ASVAGFDTVT VLSDERGLVD 200
LADLKSKVGE DTAALMLTNP NTLGLFESDI VEIAKAVHEA GGKLYYDGAN 250
SNAIMGIARP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPV GVKKDLIPYL 300
PKPIVAKTAE GFVLDYDRPE SIGRVKPFYG NFGINVRAYS YIRTMGGAGL 350
ARVSKEAVLN ANYMLARLKG AYDAPYDVYC KHEFVLSGRR QKALGVRTLD 400
IAKRLLDFGY HPPTIYFPLN VEECIMIEPT ETESKETLDD FCDAMLQIAK 450
EVEETPDVVL NAPHTTVVKR MDETLAARKP ILRYQPKQEV HV 492
Length:492
Mass (Da):53,845
Last modified:May 20, 2008 - v1
Checksum:i96ECCA89C1577794
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB60371.1.
RefSeqiYP_001813388.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB60371; ACB60371; Exig_0891.
GeneIDi6172913.
KEGGiesi:Exig_0891.
PATRICi32135363. VBIExiSib53410_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB60371.1 .
RefSeqi YP_001813388.1. NC_010556.1.

3D structure databases

ProteinModelPortali B1YLN8.
SMRi B1YLN8. Positions 8-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262543.Exig_0891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB60371 ; ACB60371 ; Exig_0891 .
GeneIDi 6172913.
KEGGi esi:Exig_0891.
PATRICi 32135363. VBIExiSib53410_0907.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ESIB262543:GHBP-967-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiGCSPB_EXIS2
AccessioniPrimary (citable) accession number: B1YLN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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