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B1YLN7 (GCSPA_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Exig_0890
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132479

Sequences

Sequence LengthMass (Da)Tools
B1YLN7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: E4A77A70874EDE0E

FASTA44848,428
        10         20         30         40         50         60 
MDFRYLPMTQ EDEKEMLQTI GADSIEDLLA DIPASVRDQG TLEEVGIPLP ETDLIRTLSK 

        70         80         90        100        110        120 
LADQNMNTKQ YPSFLGAGIY DHYAPAVVNH MLLRSEFYTA YTPYQPEISQ GELQAIFEYQ 

       130        140        150        160        170        180 
TMICELTGMD VANSSMYDGI TALAEAAMLA CAHKKKKTIV LSDGVHPEAH DVVRTYANGP 

       190        200        210        220        230        240 
GLEVETLPLV NGETAIANLD ALEDVACVIV QYPNFYGRVE DLQALADATH AKGGLFIVSA 

       250        260        270        280        290        300 
NPLALGLLEA PGKLGADITI GDCQPFGIPQ SFGGPTCGYF TTTKALMRKI PGRLVGQTVD 

       310        320        330        340        350        360 
EDGKRGFVLT LQAREQHIRR DKATSNICSN QALNALAASI AMSALGKRGI RELATRNLQT 

       370        380        390        400        410        420 
AYALKKSLIQ AGFHIVDDGP SFNEFVVELP IDATEAGKQL LQAGIIGGLP LGTFDESRSN 

       430        440 
QMLVCATELR TKEELDQFVT ALGGLTHA 

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001022 Genomic DNA. Translation: ACB60370.1.
RefSeqYP_001813387.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YLN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262543.Exig_0890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB60370; ACB60370; Exig_0890.
GeneID6173970.
KEGGesi:Exig_0890.
PATRIC32135361. VBIExiSib53410_0906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycESIB262543:GHBP-966-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_EXIS2
AccessionPrimary (citable) accession number: B1YLN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families