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B1YLN7

- GCSPA_EXIS2

UniProt

B1YLN7 - GCSPA_EXIS2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciESIB262543:GHBP-966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Exig_0890
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132479Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi262543.Exig_0890.

Structurei

3D structure databases

ProteinModelPortaliB1YLN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YLN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFRYLPMTQ EDEKEMLQTI GADSIEDLLA DIPASVRDQG TLEEVGIPLP
60 70 80 90 100
ETDLIRTLSK LADQNMNTKQ YPSFLGAGIY DHYAPAVVNH MLLRSEFYTA
110 120 130 140 150
YTPYQPEISQ GELQAIFEYQ TMICELTGMD VANSSMYDGI TALAEAAMLA
160 170 180 190 200
CAHKKKKTIV LSDGVHPEAH DVVRTYANGP GLEVETLPLV NGETAIANLD
210 220 230 240 250
ALEDVACVIV QYPNFYGRVE DLQALADATH AKGGLFIVSA NPLALGLLEA
260 270 280 290 300
PGKLGADITI GDCQPFGIPQ SFGGPTCGYF TTTKALMRKI PGRLVGQTVD
310 320 330 340 350
EDGKRGFVLT LQAREQHIRR DKATSNICSN QALNALAASI AMSALGKRGI
360 370 380 390 400
RELATRNLQT AYALKKSLIQ AGFHIVDDGP SFNEFVVELP IDATEAGKQL
410 420 430 440
LQAGIIGGLP LGTFDESRSN QMLVCATELR TKEELDQFVT ALGGLTHA
Length:448
Mass (Da):48,428
Last modified:May 20, 2008 - v1
Checksum:iE4A77A70874EDE0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB60370.1.
RefSeqiYP_001813387.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB60370; ACB60370; Exig_0890.
GeneIDi6173970.
KEGGiesi:Exig_0890.
PATRICi32135361. VBIExiSib53410_0906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB60370.1 .
RefSeqi YP_001813387.1. NC_010556.1.

3D structure databases

ProteinModelPortali B1YLN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262543.Exig_0890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB60370 ; ACB60370 ; Exig_0890 .
GeneIDi 6173970.
KEGGi esi:Exig_0890.
PATRICi 32135361. VBIExiSib53410_0906.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci ESIB262543:GHBP-966-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiGCSPA_EXIS2
AccessioniPrimary (citable) accession number: B1YLN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3