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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Exig_0890
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324791 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi262543.Exig_0890

Structurei

3D structure databases

ProteinModelPortaliB1YLN7
SMRiB1YLN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B1YLN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFRYLPMTQ EDEKEMLQTI GADSIEDLLA DIPASVRDQG TLEEVGIPLP
60 70 80 90 100
ETDLIRTLSK LADQNMNTKQ YPSFLGAGIY DHYAPAVVNH MLLRSEFYTA
110 120 130 140 150
YTPYQPEISQ GELQAIFEYQ TMICELTGMD VANSSMYDGI TALAEAAMLA
160 170 180 190 200
CAHKKKKTIV LSDGVHPEAH DVVRTYANGP GLEVETLPLV NGETAIANLD
210 220 230 240 250
ALEDVACVIV QYPNFYGRVE DLQALADATH AKGGLFIVSA NPLALGLLEA
260 270 280 290 300
PGKLGADITI GDCQPFGIPQ SFGGPTCGYF TTTKALMRKI PGRLVGQTVD
310 320 330 340 350
EDGKRGFVLT LQAREQHIRR DKATSNICSN QALNALAASI AMSALGKRGI
360 370 380 390 400
RELATRNLQT AYALKKSLIQ AGFHIVDDGP SFNEFVVELP IDATEAGKQL
410 420 430 440
LQAGIIGGLP LGTFDESRSN QMLVCATELR TKEELDQFVT ALGGLTHA
Length:448
Mass (Da):48,428
Last modified:May 20, 2008 - v1
Checksum:iE4A77A70874EDE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA Translation: ACB60370.1
RefSeqiWP_012369794.1, NC_010556.1

Genome annotation databases

EnsemblBacteriaiACB60370; ACB60370; Exig_0890
GeneIDi31769046
KEGGiesi:Exig_0890

Entry informationi

Entry nameiGCSPA_EXIS2
AccessioniPrimary (citable) accession number: B1YLN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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