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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:Exig_0889
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001140951 – 360AminomethyltransferaseAdd BLAST360

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi262543.Exig_0889

Structurei

3D structure databases

ProteinModelPortaliB1YLN6
SMRiB1YLN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43 Bacteria
COG0404 LUCA
HOGENOMiHOG000239381
KOiK00605
OMAiMPVQYPA
OrthoDBiPOG091H04FV

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
HAMAPiMF_00259 GcvT, 1 hit
InterProiView protein in InterPro
IPR006223 GCS_T
IPR022903 GCS_T_bac
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

B1YLN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTTLKRTP LFDIIAPTGK MVDFAGFEMP VLFSSIKEEH TAVRERVGMF
60 70 80 90 100
DVSHMGELFV SGSDALAFLQ QTLSNDISKI AIGQAQYNVL CQEDGGTVDD
110 120 130 140 150
LLVYRLDEQD YLLVVNASNI EKDEAHLRQY LTGDVLLENQ SDAYGQIAVQ
160 170 180 190 200
GPKAVEVLQE LTALKLEDIK FFRFAQGELA GVEMLVSRSG YTGEDGFELY
210 220 230 240 250
MPSADASAVW NALLEADVVP CGLGARDTLR FEACLPLYGH ELSATISPIE
260 270 280 290 300
AGMGFAVKPQ VKSFVGSEVL VKQKEDGPRR QLIGLELTDK GIARQDAPVL
310 320 330 340 350
VNGETIGFVT TGTLPPTIGK AIALALVPTE YATEETFEIE VRGKKLAAKR
360
IDTPFYRRSK
Length:360
Mass (Da):39,364
Last modified:May 20, 2008 - v1
Checksum:iC9B6A209B7D1942B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA Translation: ACB60369.1
RefSeqiWP_012369793.1, NC_010556.1

Genome annotation databases

EnsemblBacteriaiACB60369; ACB60369; Exig_0889
GeneIDi31769045
KEGGiesi:Exig_0889

Similar proteinsi

Entry informationi

Entry nameiGCST_EXIS2
AccessioniPrimary (citable) accession number: B1YLN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health