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B1YLN6 (GCST_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminomethyltransferase

EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:Exig_0889
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP-Rule MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP-Rule MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminomethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Aminomethyltransferase HAMAP-Rule MF_00259
PRO_1000114095

Sequences

Sequence LengthMass (Da)Tools
B1YLN6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: C9B6A209B7D1942B

FASTA36039,364
        10         20         30         40         50         60 
MSQTTLKRTP LFDIIAPTGK MVDFAGFEMP VLFSSIKEEH TAVRERVGMF DVSHMGELFV 

        70         80         90        100        110        120 
SGSDALAFLQ QTLSNDISKI AIGQAQYNVL CQEDGGTVDD LLVYRLDEQD YLLVVNASNI 

       130        140        150        160        170        180 
EKDEAHLRQY LTGDVLLENQ SDAYGQIAVQ GPKAVEVLQE LTALKLEDIK FFRFAQGELA 

       190        200        210        220        230        240 
GVEMLVSRSG YTGEDGFELY MPSADASAVW NALLEADVVP CGLGARDTLR FEACLPLYGH 

       250        260        270        280        290        300 
ELSATISPIE AGMGFAVKPQ VKSFVGSEVL VKQKEDGPRR QLIGLELTDK GIARQDAPVL 

       310        320        330        340        350        360 
VNGETIGFVT TGTLPPTIGK AIALALVPTE YATEETFEIE VRGKKLAAKR IDTPFYRRSK 

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001022 Genomic DNA. Translation: ACB60369.1.
RefSeqYP_001813386.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YLN6.
SMRB1YLN6. Positions 6-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262543.Exig_0889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB60369; ACB60369; Exig_0889.
GeneID6172953.
KEGGesi:Exig_0889.
PATRIC32135359. VBIExiSib53410_0905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHOG000239381.
KOK00605.
OMALGWLVHL.
OrthoDBEOG6T1WS5.
ProtClustDBCLSK2489187.

Enzyme and pathway databases

BioCycESIB262543:GHBP-965-MONOMER.

Family and domain databases

Gene3D2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPMF_00259. GcvT.
InterProIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. gcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_EXIS2
AccessionPrimary (citable) accession number: B1YLN6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families