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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:Exig_0721
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001289961 – 144Methylglyoxal synthaseAdd BLAST144

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_0721

Structurei

3D structure databases

ProteinModelPortaliB1YKL9
SMRiB1YKL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144MGS-likeUniRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni54 – 55Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiRACDVHN
OrthoDBiPOG091H04UH

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

B1YKL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIALIAHDE KKDEMMMFTR AYEAYFAKNT LYATGTTGQR IMEATALTVH
60 70 80 90 100
RCKSGPLGGD QEIGAMVARG EIDIVIFLRD PLTAQPHEPD VSALIRLCDV
110 120 130 140
YDLPLATNVG TAEILINGLE QGEFQWREII RKRHEEEQRK FLTD
Length:144
Mass (Da):16,296
Last modified:May 20, 2008 - v1
Checksum:i2DF2B85439FC6923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA Translation: ACB60202.1
RefSeqiWP_012369626.1, NC_010556.1

Genome annotation databases

EnsemblBacteriaiACB60202; ACB60202; Exig_0721
GeneIDi31768878
KEGGiesi:Exig_0721

Similar proteinsi

Entry informationi

Entry nameiMGSA_EXIS2
AccessioniPrimary (citable) accession number: B1YKL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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