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B1YKI7 (G6PI_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:Exig_2289
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125726

Sites

Active site3111 By similarity
Active site4251 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1YKI7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 888F46FBC456ED25

FASTA44949,448
        10         20         30         40         50         60 
MTTVRFDYSK ALQFVGQHEV DYMADTVKTL HGAIHNGTGA GSDFLGWVDL PTNYDKAEFE 

        70         80         90        100        110        120 
KIQAAAEKIK SDSDVLLVVG IGGSYLGARA AIEMLGHSFH NLLSKEERKA PQIIYAGHNI 

       130        140        150        160        170        180 
SSTYLHDLFQ VLEGKDVSVN IISKSGTTTE PAISFRLLKT FMEDKYGKAG AKDRIYATTD 

       190        200        210        220        230        240 
KARGALKTLA DSEGYQTFVI PDDVGGRFSV LTPVGLLPIA AAGISIEELM AGARDAQVQF 

       250        260        270        280        290        300 
SNENLAENEA YQYAVVRNAL YAKGKTIELL VNYEPALHYV SEWWKQLYGE SEGKDFKGIF 

       310        320        330        340        350        360 
PAAVDFSTDL HSMGQYVQEG RRDLFETVIK VGQARHALTI EKDAQDLDGL NFLEGKSIQF 

       370        380        390        400        410        420 
VNDKAAEGTL LAHTDGQVPN LTVELPEMTP YHLGFLFYFF EKACAMSGYL LGVNPFDQPG 

       430        440 
VEAYKKNMFA LLGKPGFEAE KAELEARLK

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB61740.1.
RefSeqYP_001814757.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YKI7.
SMRB1YKI7. Positions 4-448.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1YKI7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6172727.
GenomeReviewsGene locus Exig_2289 in contig CP001022_GR.
KEGGesi:Exig_2289.
PATRIC32138208. VBIExiSib53410_2326.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG615843.
OMADNLDGLN.
ProtClustDBCLSK2489761.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_EXIS2
AccessionPrimary (citable) accession number: B1YKI7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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