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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Exig_2275
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913181 – 801Leucine--tRNA ligaseAdd BLAST801

Proteomic databases

PRIDEiB1YKH4

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_2275

Structurei

3D structure databases

ProteinModelPortaliB1YKH4
SMRiB1YKH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1YKH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNHREIEP KWQARWEQDN AFVTTEDPEK EGFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT
110 120 130 140 150
AQNIETFKRQ LKDLGFSYDW DREINTTDPK YYKWTQWIFT KLYEQGLAFV
160 170 180 190 200
DEVAVNWCPA LGTVLANEEV IDGLSERGNH PVVRVPMRQW VLKITEYADR
210 220 230 240 250
LLEDLDELDW PESVKEMQRN WIGKSEGAEI DFTIDGHKKQ VTVFTTRPDT
260 270 280 290 300
VFGATYLVLA PEHPFVTDIT TEDHEEAVKA YIASVQTKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAFAV NPISGERLPI WIADYVLATY GTGAIMAVPA HDERDHEFAK
360 370 380 390 400
QFDLPIIEVV KGGNVDEVAY TGEGEHVNSQ MLDGLSKQEA IETIIAELET
410 420 430 440 450
NQVGRKKITF RLRDWLFSRQ RYWGEPIPVV HMEDGTMKTL DKSELPLELP
460 470 480 490 500
MIPEIKPSGT GESPLALAED WLDYTDPVTG LKGRRETNTM PQWGGSCWYY
510 520 530 540 550
LRFIDPHNEE AIADPEKLKY WLPVDIYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
IGVVPTKEPF QKLYNQGMIL GENNEKMSKS RGNVINPDEI VKSHGADTLR
610 620 630 640 650
LYEMFMGPLD ASVSWSENGL DGARRFLDRV WRLFERTADI QDVTTVDADF
660 670 680 690 700
ERVYHQTVKK VTEDFTNIQF NTGISQLMVF VNEANKQPVL PRHFLRGFIQ
710 720 730 740 750
LLTPVAPHLG EELWEQLGFE DTLTYAAWPT FDETKLVSDT MEFVIQVNGK
760 770 780 790 800
VRSKLVISME ATKEEIEALA FADEKTQEWI GDKTVRKVIV VPKKLINIVA

N
Length:801
Mass (Da):91,651
Last modified:May 20, 2008 - v1
Checksum:iC99750E7764ED912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA Translation: ACB61727.1
RefSeqiWP_012371144.1, NC_010556.1

Genome annotation databases

EnsemblBacteriaiACB61727; ACB61727; Exig_2275
GeneIDi31770395
KEGGiesi:Exig_2275

Similar proteinsi

Entry informationi

Entry nameiSYL_EXIS2
AccessioniPrimary (citable) accession number: B1YKH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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