B1YJN0 (B1YJN0_EXIS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Exig_0579

Organism

Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]

Taxonomic identifier

262543 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACB60060.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	69 – 76	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B1YJN0 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 0267AF1269017D05	FASTA	559	60,385
	10 20 30 40 50 60 MEKTIRSDLE IAQQTILRPI SEIAEHIGLN DADYDTYGKY KAKLTDGLVK RLATKADGKL 70 80 90 100 110 120 ILVTAINPTA AGEGKSTVTV GLGQALHRLN HKTMICLREP SLGPTMGLKG GACGGGYSQV 130 140 150 160 170 180 LPMEEINLHF TGDMHAITSA HNTISALLDN HLHQGNDLRI DPRRITWKRV LDLNDRALRQ 190 200 210 220 230 240 ITIGLGGPAH GVPRQDGFDI TVASEIMAVL CLADSITDLE KRISRIVVAY SYDQQPVTVK 250 260 270 280 290 300 DIKASGAATL LLKEAFRPNL VQTVEGTPAL IHGGPFANIA HGCNSLIATR TALKLSDYVV 310 320 330 340 350 360 TEAGFGADLG AEKFFNIKSR IGHLHPDAVV VVATVRALKM HGGVAKDQLA EENLAALVEG 370 380 390 400 410 420 LALLEKHVET MDLFGVPAVV ALNRFATDTD TERETVLEWC RERNIRVAES EVFSQGGAGG 430 440 450 460 470 480 EALAEQVFEA LEEESQFTPL YPAELPLTQK IERIAKRVYG AADVHFEEKA LRELERCTEQ 490 500 510 520 530 540 GLGHLPICMA KTPFSLTDDP SKYGRVEGFT ITVREIKPSI GAGFIVALTG NVLTMPGLPK 550 IPAANKMGIS EDGTIYGLS

References

[1]

"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001022 Genomic DNA. Translation: ACB60060.1.
RefSeq	YP_001813077.1. NC_010556.1.
3D structure databases
ProteinModelPortal	B1YJN0.
SMR	B1YJN0. Positions 8-557.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YJN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6174620.
GenomeReviews	Gene locus Exig_0579 in contig CP001022_GR.
KEGG	esi:Exig_0579.
PATRIC	32134695. VBIExiSib53410_0593.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	CLSK2489018.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1YJN0_EXIS2

Accession

Primary (citable) accession number: B1YJN0

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)