ID   B1YJI1_EXIS2            Unreviewed;       494 AA.
AC   B1YJI1;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Aldehyde Dehydrogenase {ECO:0000313|EMBL:ACB60011.1};
GN   OrderedLocusNames=Exig_0530 {ECO:0000313|EMBL:ACB60011.1};
OS   Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS   255-15).
OC   Bacteria; Bacillota; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543 {ECO:0000313|EMBL:ACB60011.1, ECO:0000313|Proteomes:UP000001681};
RN   [1] {ECO:0000313|EMBL:ACB60011.1, ECO:0000313|Proteomes:UP000001681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC   {ECO:0000313|Proteomes:UP000001681};
RX   PubMed=16489412; DOI=10.1007/s00792-005-0497-5;
RA   Rodrigues D.F., Goris J., Vishnivetskaya T., Gilichinsky D.,
RA   Thomashow M.F., Tiedje J.M.;
RT   "Characterization of Exiguobacterium isolates from the Siberian permafrost.
RT   Description of Exiguobacterium sibiricum sp. nov.";
RL   Extremophiles 10:285-294(2006).
RN   [2] {ECO:0000313|EMBL:ACB60011.1, ECO:0000313|Proteomes:UP000001681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC   {ECO:0000313|Proteomes:UP000001681};
RX   PubMed=19019206; DOI=10.1186/1471-2164-9-547;
RA   Rodrigues D.F., Ivanova N., He Z., Huebner M., Zhou J., Tiedje J.M.;
RT   "Architecture of thermal adaptation in an Exiguobacterium sibiricum strain
RT   isolated from 3 million year old permafrost: a genome and transcriptome
RT   approach.";
RL   BMC Genomics 9:547-547(2008).
RN   [3] {ECO:0000313|Proteomes:UP000001681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC   {ECO:0000313|Proteomes:UP000001681};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA   Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA   Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001022; ACB60011.1; -; Genomic_DNA.
DR   RefSeq; WP_012369435.1; NC_010556.1.
DR   AlphaFoldDB; B1YJI1; -.
DR   STRING; 262543.Exig_0530; -.
DR   KEGG; esi:Exig_0530; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_9; -.
DR   OrthoDB; 9762913at2; -.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07151; ALDH_HBenzADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42986; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   PANTHER; PTHR42986:SF1; BENZALDEHYDE DEHYDROGENASE YFMT; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001681}.
FT   DOMAIN          22..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        259
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   494 AA;  54060 MW;  8959F2F04FFDC429 CRC64;
     MQQHTKSSLN TDFTKIFING QWRKGASDSN MTNTNPFTGE TLFEISAANN DDLDDAYQSA
     KVAQKEWAKV PALKRQGLIE EFLKVMYEEK ETIVNWLIKE SGSTRIKAEG EFLASVLIVK
     EAATFPLRMH GEIRPSVVPG KENRIYRKAL GVIGVISPWN FPFHLAVRSI ATAIAIGNAV
     VVKPATDTPV SGGLIFASLF EKAGLPKGVL NVIVGRGSEI GDSIVEHPVP RLISFTGSTE
     VGRHIGELAG KHLKKTALEL GGNNVFVVLD DADLDRAVES AVYSKFYHQG QICMSTNRIL
     VAQSIHDEFV EKYVARVKEL QFGDPSNGRT QVGPLINQSQ VDRIMEEIEK TKAAGATVRV
     GGEADGNVIA PTVVTGVTND MPLAKNEIFG PVAVIIPFKD DAEALELANS LPYGLSGAVH
     GSSIERATEF ALQVETGMIH INDQSVNDEP HMPFGGEKDS GLGRFNGEWV LEEFSTVQWL
     SVMHERRQYK PFFE
//