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B1YJD5 (B1YJD5_EXIS2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Exig_2064
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region236 – 2405ACP-binding By similarity HAMAP MF_01815

Sites

Active site1111 By similarity HAMAP MF_01815
Active site2351 By similarity HAMAP MF_01815
Active site2651 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B1YJD5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 6FD6CFE6370ABBE8

FASTA31432,983
        10         20         30         40         50         60 
MNIGIVGLGT SLPEHRMTND DLAATLDTSD EWIRSRTGIG ARRIADDAVD VTDLATEAAQ 

        70         80         90        100        110        120 
KALADANLTA DDIGLIVVGT ATGRAFPSTA CIVQERIGAL GATAFDISAA CSGFIFALQT 

       130        140        150        160        170        180 
ASSMMTATGS KHALVIGAEK MSSIVDWSDR STAILFGDGA GAVVLGPTEQ QGLNAFELGT 

       190        200        210        220        230        240 
DGRGAHLLFK NLDGPIEMNG REVFKFAVRK LPDIVEKVIQ KADGTLDELD LLIPHQANLR 

       250        260        270        280        290        300 
IIDAARERLG IAEEKVIVTI DEHANTSAAS IPLALEEARR QGRLSPGTTL VLAGFGAGLT 

       310 
WGAAYITWTK GENT

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB61516.1.
RefSeqYP_001814533.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YJD5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1YJD5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6173180.
GenomeReviewsGene locus Exig_2064 in contig CP001022_GR.
KEGGesi:Exig_2064.
PATRIC32137750. VBIExiSib53410_2098.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAKEIGAIN.
ProtClustDBCLSK2489635.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1YJD5_EXIS2
AccessionPrimary (citable) accession number: B1YJD5
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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