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B1YJ07

- PUR5_EXIS2

UniProt

B1YJ07 - PUR5_EXIS2

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, Exig_0455
Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciESIB262543:GHBP-508-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Exig_0455
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000193024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_0455.

Structurei

3D structure databases

ProteinModelPortaliB1YJ07.
SMRiB1YJ07. Positions 14-339.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiPDMYGAD.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YJ07-1 [UniParc]FASTAAdd to Basket

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MSKQYEAAGV SLTAGYESVS RMKKHVARSM RKEVMTGLGS FGAMFDLSQL    50
NLKEPVLVSG TDGVGTKLKL AFALDQHDTI GIDCVAMCVN DIIVQGAEPL 100
YFLDYIALGK AIPAKIERIV AGVAEGCVQS GCTLIGGETA EMPGMYADGE 150
YDIAGFAVGA VEKQKLITGE HVQPGDVILG LASSGVHSNG FSLVRKIVAE 200
SGLRYEDELM MFGSTIGNTL LMPTRIYVEA VKAALETEKI QAMVHITGGG 250
FYENVPRVLP EGCGATFDPK KWPTLPVFDW LEQAGNVPRH DMYNVFNMGI 300
GYMMIVKPED VAAVSARLAR ENETVYTIGT VTSEPGVRIL GVDQ 344
Length:344
Mass (Da):36,927
Last modified:May 20, 2008 - v1
Checksum:iC1A234697CB7F327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB59937.1.
RefSeqiYP_001812954.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB59937; ACB59937; Exig_0455.
GeneIDi6173297.
KEGGiesi:Exig_0455.
PATRICi32134441. VBIExiSib53410_0469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB59937.1 .
RefSeqi YP_001812954.1. NC_010556.1.

3D structure databases

ProteinModelPortali B1YJ07.
SMRi B1YJ07. Positions 14-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262543.Exig_0455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB59937 ; ACB59937 ; Exig_0455 .
GeneIDi 6173297.
KEGGi esi:Exig_0455.
PATRICi 32134441. VBIExiSib53410_0469.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi PDMYGAD.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ESIB262543:GHBP-508-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiPUR5_EXIS2
AccessioniPrimary (citable) accession number: B1YJ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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