Skip Header

Contribute Send feedback
Read comments (?) or add your own

B1YIR5 (B1YIR5_EXIS2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Exig_1939
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region117 – 12595-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1211Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
B1YIR5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: B912A1B0E3EFC9B1

FASTA21422,865
        10         20         30         40         50         60 
MNQLAQALLE IEAVTLAPTA PYTWASGLRS PIYCDNRLTL SSPAVRTLIA DKLAERIRPL 

        70         80         90        100        110        120 
NADVIAGTAT AGIPHAALVA ERLGLPMVYI RGSAKGHGKG NQIEGRLQAG QRVIVVEDLL 

       130        140        150        160        170        180 
STGMSSIEAT QAVEAAGASV IRIQAIFSYG MTRLKENLTA AGVEADALLT FTELLETAVE 

       190        200        210 
TAYISKEEQE GLQTWSIDPV KWSESFLIGT KQNS

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB61391.1.
RefSeqYP_001814408.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YIR5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1YIR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6173292.
GenomeReviewsGene locus Exig_1939 in contig CP001022_GR.
KEGGesi:Exig_1939.
PATRIC32137496. VBIExiSib53410_1971.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBCLSK2489552.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1YIR5_EXIS2
AccessionPrimary (citable) accession number: B1YIR5
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info