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B1YI57

- PNP_EXIS2

UniProt

B1YI57 - PNP_EXIS2

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Exig_1832
Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciESIB262543:GHBP-1910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Exig_1832
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000147920Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_1832.

Structurei

3D structure databases

ProteinModelPortaliB1YI57.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHAdd
BLAST
Domaini624 – 69269S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YI57-1 [UniParc]FASTAAdd to Basket

« Hide

MSQTKQTFST ELGGRPLTIE IGQLAKQANG AALIRYGETA VLATVVASKQ    50
PKDLDFFPLT VNYEEKLYAA GKIPGGFLKR EGRPGENAIL TSRLIDRPIR 100
PLFPDGFRHD IQVATTVLSS DEDNSPEVAA MIGASIALSI SDIPFDGPIA 150
GVTIGRVNGE FIINPTMSQA SESDIDLQVA GTKHAVNMVE AGAKEVSEQA 200
MLEAILLGHD VIKELIAFQE EIVAAVGQEK FAYTVASFDE TLVNRLKAEA 250
LAEVTTAVQV EEKQARDLAI NEVISKYIDQ YAADDSITEA QLAEVSGVLN 300
KFVKTEVRRL ITEDKVRPDG RGLAEIRPLD SEIGLLPRAH GSGLFTRGQT 350
QVLSVATLGV AGDAQIIDGL GLKAEKRFMH HYNFPPFSVG EARPMRAPGR 400
REIGHGALGE RALLPVLPSE TDFPYTIRLV SEVLESNGSS SQASICGSIL 450
AMMDAGVPLK APVAGIAMGL IKEGENYSIL TDIQGMEDHL GDMDFKVAGT 500
KDGVTALQMD MKIGGITRQI LEEALEQARL GRLHILEHMN SVIAEPRVEL 550
SKYAPKIVTL KINPDKIRDV IGPGGKVING IIDETGVKID IDQDGTVFIA 600
STDQDGINHA RQLIEDIVRE VVIGEEFDGT VRRVEKFGAF VELFKGKDAL 650
VHISELALER VGQTEDVVKL GDKLKVRVTE VDDKGRVNAS HKVLLVEGMS 700
PEDRAAYDEK KKTERDSRPP RRDTGSRPPR DGQRPPRRN 739
Length:739
Mass (Da):80,270
Last modified:May 20, 2008 - v1
Checksum:i6887E5184326EE4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB61284.1.
RefSeqiYP_001814301.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB61284; ACB61284; Exig_1832.
GeneIDi6173923.
KEGGiesi:Exig_1832.
PATRICi32137282. VBIExiSib53410_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001022 Genomic DNA. Translation: ACB61284.1 .
RefSeqi YP_001814301.1. NC_010556.1.

3D structure databases

ProteinModelPortali B1YI57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262543.Exig_1832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB61284 ; ACB61284 ; Exig_1832 .
GeneIDi 6173923.
KEGGi esi:Exig_1832.
PATRICi 32137282. VBIExiSib53410_1864.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ESIB262543:GHBP-1910-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiPNP_EXIS2
AccessioniPrimary (citable) accession number: B1YI57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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