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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi488MagnesiumUniRule annotation1
Metal bindingi494MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Exig_1832
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479201 – 739Polyribonucleotide nucleotidyltransferaseAdd BLAST739

Proteomic databases

PRIDEiB1YI57

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_1832

Structurei

3D structure databases

ProteinModelPortaliB1YI57
SMRiB1YI57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 614KHUniRule annotationAdd BLAST60
Domaini624 – 692S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B1YI57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKQTFST ELGGRPLTIE IGQLAKQANG AALIRYGETA VLATVVASKQ
60 70 80 90 100
PKDLDFFPLT VNYEEKLYAA GKIPGGFLKR EGRPGENAIL TSRLIDRPIR
110 120 130 140 150
PLFPDGFRHD IQVATTVLSS DEDNSPEVAA MIGASIALSI SDIPFDGPIA
160 170 180 190 200
GVTIGRVNGE FIINPTMSQA SESDIDLQVA GTKHAVNMVE AGAKEVSEQA
210 220 230 240 250
MLEAILLGHD VIKELIAFQE EIVAAVGQEK FAYTVASFDE TLVNRLKAEA
260 270 280 290 300
LAEVTTAVQV EEKQARDLAI NEVISKYIDQ YAADDSITEA QLAEVSGVLN
310 320 330 340 350
KFVKTEVRRL ITEDKVRPDG RGLAEIRPLD SEIGLLPRAH GSGLFTRGQT
360 370 380 390 400
QVLSVATLGV AGDAQIIDGL GLKAEKRFMH HYNFPPFSVG EARPMRAPGR
410 420 430 440 450
REIGHGALGE RALLPVLPSE TDFPYTIRLV SEVLESNGSS SQASICGSIL
460 470 480 490 500
AMMDAGVPLK APVAGIAMGL IKEGENYSIL TDIQGMEDHL GDMDFKVAGT
510 520 530 540 550
KDGVTALQMD MKIGGITRQI LEEALEQARL GRLHILEHMN SVIAEPRVEL
560 570 580 590 600
SKYAPKIVTL KINPDKIRDV IGPGGKVING IIDETGVKID IDQDGTVFIA
610 620 630 640 650
STDQDGINHA RQLIEDIVRE VVIGEEFDGT VRRVEKFGAF VELFKGKDAL
660 670 680 690 700
VHISELALER VGQTEDVVKL GDKLKVRVTE VDDKGRVNAS HKVLLVEGMS
710 720 730
PEDRAAYDEK KKTERDSRPP RRDTGSRPPR DGQRPPRRN
Length:739
Mass (Da):80,270
Last modified:May 20, 2008 - v1
Checksum:i6887E5184326EE4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA Translation: ACB61284.1
RefSeqiWP_012370702.1, NC_010556.1

Genome annotation databases

EnsemblBacteriaiACB61284; ACB61284; Exig_1832
GeneIDi31769958
KEGGiesi:Exig_1832

Similar proteinsi

Entry informationi

Entry nameiPNP_EXIS2
AccessioniPrimary (citable) accession number: B1YI57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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