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B1YI57

- PNP_EXIS2

UniProt

B1YI57 - PNP_EXIS2

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciESIB262543:GHBP-1910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Exig_1832
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000001681: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Polyribonucleotide nucleotidyltransferasePRO_1000147920Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_1832.

Structurei

3D structure databases

ProteinModelPortaliB1YI57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YI57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQTKQTFST ELGGRPLTIE IGQLAKQANG AALIRYGETA VLATVVASKQ
60 70 80 90 100
PKDLDFFPLT VNYEEKLYAA GKIPGGFLKR EGRPGENAIL TSRLIDRPIR
110 120 130 140 150
PLFPDGFRHD IQVATTVLSS DEDNSPEVAA MIGASIALSI SDIPFDGPIA
160 170 180 190 200
GVTIGRVNGE FIINPTMSQA SESDIDLQVA GTKHAVNMVE AGAKEVSEQA
210 220 230 240 250
MLEAILLGHD VIKELIAFQE EIVAAVGQEK FAYTVASFDE TLVNRLKAEA
260 270 280 290 300
LAEVTTAVQV EEKQARDLAI NEVISKYIDQ YAADDSITEA QLAEVSGVLN
310 320 330 340 350
KFVKTEVRRL ITEDKVRPDG RGLAEIRPLD SEIGLLPRAH GSGLFTRGQT
360 370 380 390 400
QVLSVATLGV AGDAQIIDGL GLKAEKRFMH HYNFPPFSVG EARPMRAPGR
410 420 430 440 450
REIGHGALGE RALLPVLPSE TDFPYTIRLV SEVLESNGSS SQASICGSIL
460 470 480 490 500
AMMDAGVPLK APVAGIAMGL IKEGENYSIL TDIQGMEDHL GDMDFKVAGT
510 520 530 540 550
KDGVTALQMD MKIGGITRQI LEEALEQARL GRLHILEHMN SVIAEPRVEL
560 570 580 590 600
SKYAPKIVTL KINPDKIRDV IGPGGKVING IIDETGVKID IDQDGTVFIA
610 620 630 640 650
STDQDGINHA RQLIEDIVRE VVIGEEFDGT VRRVEKFGAF VELFKGKDAL
660 670 680 690 700
VHISELALER VGQTEDVVKL GDKLKVRVTE VDDKGRVNAS HKVLLVEGMS
710 720 730
PEDRAAYDEK KKTERDSRPP RRDTGSRPPR DGQRPPRRN
Length:739
Mass (Da):80,270
Last modified:May 20, 2008 - v1
Checksum:i6887E5184326EE4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB61284.1.
RefSeqiYP_001814301.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB61284; ACB61284; Exig_1832.
GeneIDi6173923.
KEGGiesi:Exig_1832.
PATRICi32137282. VBIExiSib53410_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB61284.1 .
RefSeqi YP_001814301.1. NC_010556.1.

3D structure databases

ProteinModelPortali B1YI57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262543.Exig_1832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB61284 ; ACB61284 ; Exig_1832 .
GeneIDi 6173923.
KEGGi esi:Exig_1832.
PATRICi 32137282. VBIExiSib53410_1864.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ESIB262543:GHBP-1910-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17290 / JCM 13490 / 255-15.

Entry informationi

Entry nameiPNP_EXIS2
AccessioniPrimary (citable) accession number: B1YI57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3