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B1YHT1 (GCH4_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Exig_0229
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium ›

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301GTP cyclohydrolase folE2 HAMAP-Rule MF_01527
PRO_0000372028

Sites

Site1831May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
B1YHT1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: E87B3E9FECA72F7D

FASTA30134,076
        10         20         30         40         50         60 
MSTYPVTLPT KEERHKLFGS VPPIKGTKPT EKDKMIDLQN TPKNFLFALD AVGISNVKHP 

        70         80         90        100        110        120 
VVIQDGETTQ ATIATFELST SLVQDRKGIN MSRLTEQLDQ YHNEGWVVTN ESLIQFAREL 

       130        140        150        160        170        180 
AERMEQSEGQ LTIRYPWFFT RKAPATGLSG LMNAEVWQTV SVNTETNEAT LSVGLTINVT 

       190        200        210        220        230        240 
TLCPCSKEIS EYSAHNQRGY VTMEASLRDE ADDFNWKQEL LDAAESNASA PLHPVLKRPD 

       250        260        270        280        290        300 
EKRVTEMAYE NPRFVEDMVR LIAADLYEMD PIASFFVECR NEETIHQHDA IARITFDKDA 


Q

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References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB59715.1.
RefSeqYP_001812732.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YHT1.
ModBaseSearch...

Protein-protein interaction databases

STRING262543.Exig_0229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB59715; ACB59715; Exig_0229.
GeneID6173204.
KEGGesi:Exig_0229.
PATRIC32133977. VBIExiSib53410_0240.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycESIB262543:GHBP-280-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_EXIS2
AccessionPrimary (citable) accession number: B1YHT1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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