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B1YHJ8 (MTLD_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:Exig_1718
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000099193

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B1YHJ8 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 67AA01205BAB3DD6

FASTA38142,268
        10         20         30         40         50         60 
MKAVHFGAGN IGRGFIGLQL VKSGYDVCFI DVNAEVVEAL KTRGAYTVGY AAEEAAVEEV 

        70         80         90        100        110        120 
SRVTALNSQT EAERVVEAIA TADVVTTAVG PTLLARIAPL LAEGLKQRTT TQNVFVIACE 

       130        140        150        160        170        180 
NMIEGSSHLQ QEVMHYLEST PGNVFFPNAA VDRIVPLQHH EDPLYVEVEP FFEWVIETKA 

       190        200        210        220        230        240 
LPDDYPVFEG VTYVADITPF IERKLFTVNT GHAIASYLGA LFGKETIAES LQDVRVRRGV 

       250        260        270        280        290        300 
QSALYETGWL LLEKYGFDPK DHSAYIQKNI KRFENPRIHD EIVRVARSPI RKLGPRDRLV 

       310        320        330        340        350        360 
KPARELMDRG IEANGLALGI AAALTYSDPN YSEYSELNTF IEQNGIQETV ATYLGLEADE 

       370        380 
RLSQLIVSQY EQMHPMSDSI A

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB61171.1.
RefSeqYP_001814188.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YHJ8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1YHJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6174755.
GenomeReviewsGene locus Exig_1718 in contig CP001022_GR.
KEGGesi:Exig_1718.
PATRIC32137046. VBIExiSib53410_1747.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBCLSK2489393.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_EXIS2
AccessionPrimary (citable) accession number: B1YHJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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