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B1YHD6

- KYNU_EXIS2

UniProt

B1YHD6 - KYNU_EXIS2

Protein

Kynureninase

Gene

kynU

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei101 – 1011Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
    Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
    Binding sitei213 – 2131Pyridoxal phosphateUniRule annotation
    Binding sitei235 – 2351Pyridoxal phosphateUniRule annotation
    Binding sitei264 – 2641Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciESIB262543:GHBP-233-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Exig_0182
    OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
    Taxonomic identifieri262543 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000001681: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425KynureninasePRO_0000357004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262543.Exig_0182.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YHD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1324Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiGLMNDIV.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1YHD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLTAPRKHA IEQDQQDALA PYRNEFYLQE GSIYMDGNSL GLLSKRAEAT    50
    LLESLADWRE LGIDGWMKGR HPWFDLSEKL AALNAPLVGG RADEVMVTGS 100
    TTVNLHQLVA TFFAPSGRRT KILADSLTFP SDIYALQSQL RLRGLDPAEH 150
    LVQVESRDGR FLDEADIIAA MTDDIALIVL PTVLYRSGQI LDMERLTREA 200
    HARGILIGFD GCHSVGAIPH AFHDWGVDFA YWCNYKHLNG GPGTVGGLFV 250
    HERHFGTLPG LTGWFGSRKD KQFDMNHTMT PAENAAAFQI GTPHVLSLAP 300
    QIGALELFAE VGIDAVRAKS LALTDYMMTL VDQELTAYGF VIGNPRDAKR 350
    RGAHLSLEHP EAARICKALK AHQVIPDFRA PNIVRLAPVA LYNSFEDVYE 400
    VVSILKTIMD EKQYEQFKNE REVVA 425
    Length:425
    Mass (Da):47,194
    Last modified:May 20, 2008 - v1
    Checksum:i8BDA1A8D2351607D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001022 Genomic DNA. Translation: ACB59668.1.
    RefSeqiYP_001812685.1. NC_010556.1.

    Genome annotation databases

    EnsemblBacteriaiACB59668; ACB59668; Exig_0182.
    GeneIDi6173872.
    KEGGiesi:Exig_0182.
    PATRICi32133885. VBIExiSib53410_0194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001022 Genomic DNA. Translation: ACB59668.1 .
    RefSeqi YP_001812685.1. NC_010556.1.

    3D structure databases

    ProteinModelPortali B1YHD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262543.Exig_0182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB59668 ; ACB59668 ; Exig_0182 .
    GeneIDi 6173872.
    KEGGi esi:Exig_0182.
    PATRICi 32133885. VBIExiSib53410_0194.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi GLMNDIV.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci ESIB262543:GHBP-233-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17290 / JCM 13490 / 255-15.

    Entry informationi

    Entry nameiKYNU_EXIS2
    AccessioniPrimary (citable) accession number: B1YHD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3