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B1YH73 (GUAC_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Exig_1681
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium ›

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP-Rule MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP-Rule MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionGMP reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328GMP reductase HAMAP-Rule MF_01511
PRO_1000146135

Regions

Nucleotide binding205 – 22824NADP Potential

Sites

Active site1761Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1YH73 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 366A2DB2B0AC8A5E

FASTA32836,074
        10         20         30         40         50         60 
MMDVVFDYED IQLIPAKSIV GSRSECDTTV EFGGRRFKLP VVPANMQTII DEKIATFLAE 

        70         80         90        100        110        120 
NGYFYIMHRF EPETRLNFVR EMQQRGLIAS ISVGVKTEEY TFIETLAQEG LTPEYITIDI 

       130        140        150        160        170        180 
AHGHSEAVIR MIQHIKQILP ESFVIAGNVG TPEAVRELEH AGADATKVGI GPGKVCITKI 

       190        200        210        220        230        240 
KTGFGTGGWQ LAALRWCAKA ASKPIIADGG IRTHGDIAKS VRFGATMVMI GSLFAGHEES 

       250        260        270        280        290        300 
PGEMQEVDGL QVKEYFGSAS EFQKGEKKNV EGKKMFIEFK GSLSDTLTEM EQDLQSAISY 

       310        320 
AGGNKLQAIR TVDYVVVKNS IFNGDKVY

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB61134.1.
RefSeqYP_001814151.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YH73.
SMRB1YH73. Positions 5-321.
ModBaseSearch...

Protein-protein interaction databases

STRING262543.Exig_1681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB61134; ACB61134; Exig_1681.
GeneID6175487.
KEGGesi:Exig_1681.
PATRIC32136970. VBIExiSib53410_1710.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHOG000165753.
KOK00364.
OMACSCAGDV.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycESIB262543:GHBP-1756-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01511. GMP_reduct_type2.
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_EXIS2
AccessionPrimary (citable) accession number: B1YH73
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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