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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:Exig_3002
OrganismiExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Taxonomic identifieri262543 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
Proteomesi
  • UP000001681 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000998721 – 497Probable malate:quinone oxidoreductaseAdd BLAST497

Interactioni

Protein-protein interaction databases

STRINGi262543.Exig_3002.

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YG64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSMPKQTDV ILIGAGVMSA TLGVLLKELA PDMKIKVFEK LASAGEESSN
60 70 80 90 100
EWNNAGTGHA ALCELNYTTE NADGTIDISK AVKVNEQFQL SRQFWSHLVK
110 120 130 140 150
EQVLPNPKEF IMPIPHMSMV EGAENVTFLK KRLEALSANP LFKGMEFSED
160 170 180 190 200
PEQLKEWIPL IMEGRTSPEP IAATKIDSGT DVNFGALTRI LFDHLKQLDV
210 220 230 240 250
EINYGHGVED LKRVDGGWEI KVKNERDNRI EHHTAKFVFI GGGGGSLPLL
260 270 280 290 300
QKTGIPESKQ IGGFPVSGLF LVCKNPEIAE RHHAKVYGKA KVGAPPMSVP
310 320 330 340 350
HLDTRYIDGQ KSLLFGPFAG FSPKFLKTGS NLDLITSVKP NNVLTMLAAG
360 370 380 390 400
AKEMGLTKYL IEQVLLSTEQ RMNELREFIP NAKTEDWDVV VAGQRVQVIK
410 420 430 440 450
DTPQGKGALQ FGTEVVSAAD GSVAALLGAS PGASTAVPVM LEVLAKCFPD
460 470 480 490
QLPSWEAKIK EMIPSYGTSL VANPELFDQI HAETTKTLEL TEAQPIR
Length:497
Mass (Da):54,253
Last modified:May 20, 2008 - v1
Checksum:iF6CF3CB731DF1C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB62448.1.
RefSeqiWP_012371863.1. NC_010556.1.

Genome annotation databases

EnsemblBacteriaiACB62448; ACB62448; Exig_3002.
KEGGiesi:Exig_3002.
PATRICi32139680. VBIExiSib53410_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001022 Genomic DNA. Translation: ACB62448.1.
RefSeqiWP_012371863.1. NC_010556.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262543.Exig_3002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB62448; ACB62448; Exig_3002.
KEGGiesi:Exig_3002.
PATRICi32139680. VBIExiSib53410_3045.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_EXIS2
AccessioniPrimary (citable) accession number: B1YG64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.