B1YG64 (MQO_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	Exig_3002

Organism

Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]

Taxonomic identifier

262543 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_1000099872

Sequences

	Sequence		Length	Mass (Da)
	B1YG64 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: F6CF3CB731DF1C72	FASTA	497	54,253
	10 20 30 40 50 60 MSSMPKQTDV ILIGAGVMSA TLGVLLKELA PDMKIKVFEK LASAGEESSN EWNNAGTGHA 70 80 90 100 110 120 ALCELNYTTE NADGTIDISK AVKVNEQFQL SRQFWSHLVK EQVLPNPKEF IMPIPHMSMV 130 140 150 160 170 180 EGAENVTFLK KRLEALSANP LFKGMEFSED PEQLKEWIPL IMEGRTSPEP IAATKIDSGT 190 200 210 220 230 240 DVNFGALTRI LFDHLKQLDV EINYGHGVED LKRVDGGWEI KVKNERDNRI EHHTAKFVFI 250 260 270 280 290 300 GGGGGSLPLL QKTGIPESKQ IGGFPVSGLF LVCKNPEIAE RHHAKVYGKA KVGAPPMSVP 310 320 330 340 350 360 HLDTRYIDGQ KSLLFGPFAG FSPKFLKTGS NLDLITSVKP NNVLTMLAAG AKEMGLTKYL 370 380 390 400 410 420 IEQVLLSTEQ RMNELREFIP NAKTEDWDVV VAGQRVQVIK DTPQGKGALQ FGTEVVSAAD 430 440 450 460 470 480 GSVAALLGAS PGASTAVPVM LEVLAKCFPD QLPSWEAKIK EMIPSYGTSL VANPELFDQI 490 HAETTKTLEL TEAQPIR

References

[1]

"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001022 Genomic DNA. Translation: ACB62448.1.
RefSeq	YP_001815465.1. NC_010556.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B1YG64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6175378.
GenomeReviews	Gene locus Exig_3002 in contig CP001022_GR.
KEGG	esi:Exig_3002.
PATRIC	32139680. VBIExiSib53410_3045.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG289663.
OMA	KKWVPLM.
ProtClustDB	PRK05257.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_EXIS2

Accession

Primary (citable) accession number: B1YG64

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program