B1YG43 (HTPG_EXIS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HtpG

Alternative name(s):
Heat shock protein HtpG
High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	Exig_2981

Organism

Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP]

Taxonomic identifier

262543 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillales incertae sedis › Bacillales Family XII. Incertae Sedis › Exiguobacterium › Exiguobacterium sibiricum

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity. HAMAP-Rule MF_00505
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00505
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00505.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 621	621	Chaperone protein HtpG HAMAP-Rule MF_00505		PRO_1000127028
Regions
	Region	1 – 340	340	A; substrate-binding By similarity
	Region	341 – 547	207	B By similarity
	Region	548 – 621	74	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1YG43 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 6CF94EFA96023300	FASTA	621	71,609
	10 20 30 40 50 60 METKQFKAES KRLLEMMIHS IYTHKEIFLR ELISNASDAM DKIYYKALTD ETITFDKDAY 70 80 90 100 110 120 KITIEPNKET RQLILRDTGI GMTKDELEEN LGTIAKSGSL AFKAENESKD GHDIIGQFGV 130 140 150 160 170 180 GFYSAFMVAD TVTVVTKPFG SDVAYKWESH GVDGYTIEEV EKEMVGTDIT LHIKANEEDE 190 200 210 220 230 240 NYDEYLEPYR LRSIIKKYSD FIRYPIEMEE TEQRPVEGSD ETESVTVMKT VNSMVPIWRK 250 260 270 280 290 300 NKRELTDEDY RNFYQEKRYG FDAPIKHIHI SADGAVRYQS ILFIPEQPSF DYYSKEFEKG 310 320 330 340 350 360 LELYANGVLI MEKCSDLLPD HFSFVKGMVD SEDLSLNISR EMLQHDRQLK LIAKNIQSKI 370 380 390 400 410 420 KTQLEALLRD DREKYETFYQ AFGRQLKFGI YNDYGMQKDT VKDLVLFHSA KEKKLVTLAE 430 440 450 460 470 480 YVAAMPEEQK YIYYASGEST DRLDKLPQSE LVKDKGFDIL YFTEEIDEFA IQMLLNYDGK 490 500 510 520 530 540 EFKSVTSSDL GIEQTEQAET TETQAEMFKA MQEVLAGHVK EVKASTRLKS HPVCFATDGA 550 560 570 580 590 600 VSIEMEKILK AMPNNQDVAA VKILELNTSH DVFRAIETAY AEDRPKFERY TKLMYQQALL 610 620 MEGLPIEDPV AFANEVCALM I

References

[1]

"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001022 Genomic DNA. Translation: ACB62427.1.
RefSeq	YP_001815444.1. NC_010556.1.
3D structure databases
ProteinModelPortal	B1YG43.
ModBase	Search...
Protein-protein interaction databases
STRING	262543.Exig_2981.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB62427; ACB62427; Exig_2981.
GeneID	6175186.
KEGG	esi:Exig_2981.
PATRIC	32139638. VBIExiSib53410_3024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0326.
HOGENOM	HOG000031989.
KO	K04079.
OMA	LTDSPAC.
ProtClustDB	PRK05218.
Enzyme and pathway databases
BioCyc	ESIB262543:GHBP-3079-MONOMER.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
HAMAP	MF_00505. HSP90.
InterPro	IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit.
Pfam	PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPG_EXIS2

Accession

Primary (citable) accession number: B1YG43

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	May 29, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program